TY - JOUR
T1 - Photodynamic therapy of head and neck cancers
AU - Biel, Merrill A.
PY - 1995
Y1 - 1995
N2 - Sixty‐five patients with neoplastic diseases of the larynx, oral cavity, pharynx, and skin have been treated with photodynamic therapy (PDT) with follow‐up to 56 months. Patients with carcinoma in situ (CIS) and T1 carcinomas obtained a complete response after one PDT treatment. All but two have remained free of disease. Eight patients with T2 and T3 carcinomas treated with PDT obtained a complete response, but they all recurred locally. This is due to the inability to adequately deliver laser light to the depths of the tumor bed. Five patients with massive neck recurrences of squamous cell carcinomas were treated with intraoperative adjuvant PDT following tumor resection. Only one developed recurrence with 24‐month follow‐up. PDT is highly effective for the curative treatment of early carcinomas (CIS, T1) of the head and neck. Also, intraoperative adjuvant PDT may increase cure rates of large infiltrating carcinomas of the head and neck. © 1995 Wiley‐Liss, Inc.
AB - Sixty‐five patients with neoplastic diseases of the larynx, oral cavity, pharynx, and skin have been treated with photodynamic therapy (PDT) with follow‐up to 56 months. Patients with carcinoma in situ (CIS) and T1 carcinomas obtained a complete response after one PDT treatment. All but two have remained free of disease. Eight patients with T2 and T3 carcinomas treated with PDT obtained a complete response, but they all recurred locally. This is due to the inability to adequately deliver laser light to the depths of the tumor bed. Five patients with massive neck recurrences of squamous cell carcinomas were treated with intraoperative adjuvant PDT following tumor resection. Only one developed recurrence with 24‐month follow‐up. PDT is highly effective for the curative treatment of early carcinomas (CIS, T1) of the head and neck. Also, intraoperative adjuvant PDT may increase cure rates of large infiltrating carcinomas of the head and neck. © 1995 Wiley‐Liss, Inc.
KW - larynx
KW - oral cavity
KW - photodynamic therapy
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U2 - 10.1002/ssu.2980110505
DO - 10.1002/ssu.2980110505
M3 - Article
C2 - 7569557
AN - SCOPUS:0029127314
SN - 8756-0437
VL - 11
SP - 355
EP - 359
JO - Seminars in Surgical Oncology
JF - Seminars in Surgical Oncology
IS - 5
ER -