Physical and chemical characterization of a porous phosphate-modified zirconia substrate

Wes A. Schafer, Peter W Carr, E. F. Funkenbusch, K. A. Parson

Research output: Contribution to journalArticlepeer-review

82 Scopus citations

Abstract

A phosphate modification of previously described porous zirconium oxide high-performance liquid chromatographic support particles has been developed. Modification of the surface with inorganic phosphate alleviates the irreversible adsorption of proteins on the native oxide surface and makes the surface more biocompatible. X-ray photoelectron spectroscopic, solid-state 31P NMR, elemental analysis, pH stability and 32P phosphate release studies that have been used to characterize physically the surface of these modified particles are reported.

Original languageEnglish (US)
Pages (from-to)137-147
Number of pages11
JournalJournal of Chromatography A
Volume587
Issue number2
DOIs
StatePublished - Dec 20 1991

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