TY - JOUR
T1 - Physical Dependence on Nicotine in Gum
T2 - A Placebo Substitution Trial
AU - Hughes, John R.
AU - Hatsukami, Dorothy K.
AU - Skoog, Kelli P.
PY - 1986/6/20
Y1 - 1986/6/20
N2 - To test whether ex-smokers become physically dependent on nicotine in gum, we entered eight ex-smokers who were using nicotine gum into a randomized, double-blind, placebo-substitution trial. When placebo was substituted, seven of the eight subjects were observed to have withdrawal symptoms and two relapsed to smoking or nicotine gum. This result suggests that physical dependence (ie, withdrawal) may be a cause of behavioral dependence on nicotine gum (ie, use of gum beyond the recommended period) and physicians should emphasize the need for gradual reduction of nicotine gum.
AB - To test whether ex-smokers become physically dependent on nicotine in gum, we entered eight ex-smokers who were using nicotine gum into a randomized, double-blind, placebo-substitution trial. When placebo was substituted, seven of the eight subjects were observed to have withdrawal symptoms and two relapsed to smoking or nicotine gum. This result suggests that physical dependence (ie, withdrawal) may be a cause of behavioral dependence on nicotine gum (ie, use of gum beyond the recommended period) and physicians should emphasize the need for gradual reduction of nicotine gum.
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U2 - 10.1001/jama.1986.03370230083036
DO - 10.1001/jama.1986.03370230083036
M3 - Article
C2 - 3712681
AN - SCOPUS:0022599560
SN - 0098-7484
VL - 255
SP - 3277
EP - 3279
JO - JAMA: The Journal of the American Medical Association
JF - JAMA: The Journal of the American Medical Association
IS - 23
ER -