Physical dependence on opiate-like peptides

Eddie Wei, Horace Loh

Research output: Contribution to journalArticlepeer-review

155 Scopus citations


Methionine-enkephalin and β-endorphin, endogenous peptides with activities similar to those of opiates, were infused for 70 hours into the periaqueductal gray-fourth ventricular spaces of the rat brain. When challenged with a naloxone, a specific opiate antagonist, these animals manifested a typical morphine-like withdrawal syndrome. These results show that such peptides can cause physical dependence.

Original languageEnglish (US)
Pages (from-to)1262-1263
Number of pages2
Issue number4259
StatePublished - Jan 1 1976

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