TY - JOUR
T1 - Physiological Effects of Concentrated Barley β-Glucan in Mildly Hypercholesterolemic Adults
AU - Smith, Kristen N.
AU - Queenan, Katie M.
AU - Fulcher, R. Gary
AU - Slavin, Joanne L
AU - Thomas, William
PY - 2008/6/1
Y1 - 2008/6/1
N2 - Objective: Barley fiber rich in beta-glucans lowers serum lipids, but is difficult to incorporate into products acceptable to consumers. We investigated the physiological effects of two concentrated barley β-glucans on cardiovascular disease (CVD) endpoints and body weight in human subjects. Methods: Hypercholesterolemic men and women (n = 90) were randomly assigned to one of two treatments: low molecular weight (low-MW) or high molecular weight (high-MW) concentrated barley β-glucan consumed as a daily supplement containing 6 grams beta-glucan/day. Fasting blood samples were collected at baseline and week 6 and analyzed for total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, glucose, insulin, homocysteine and C-reactive protein (CRP). Dietary intakes, body weights, blood pressure, hunger ratings, and gastrointestinal symptoms were measured at baseline and 6 weeks. Results: The only difference between treatments in lipid outcomes at week 6 was a reduction of the cholesterol/HDL ratio in the low-MW group and a small increase in the high-MW group. No changes were found in blood pressure, glucose, insulin, and gastrointestinal symptoms. Body weight decreased from baseline to 6 weeks in the high-MW group while body weight increased in the low-MW group. Levels of hunger decreased slightly in the low-MW group and decreased significantly in the high-MW group (P = 0.02) Conclusion: Overall, supplementation with isolated barley β-glucans of different molecular weights had small effects on cardiovascular disease markers. Molecular weight of the barley fiber did alter effects on body weight with the high-MW fiber significantly decreasing body weight.
AB - Objective: Barley fiber rich in beta-glucans lowers serum lipids, but is difficult to incorporate into products acceptable to consumers. We investigated the physiological effects of two concentrated barley β-glucans on cardiovascular disease (CVD) endpoints and body weight in human subjects. Methods: Hypercholesterolemic men and women (n = 90) were randomly assigned to one of two treatments: low molecular weight (low-MW) or high molecular weight (high-MW) concentrated barley β-glucan consumed as a daily supplement containing 6 grams beta-glucan/day. Fasting blood samples were collected at baseline and week 6 and analyzed for total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, glucose, insulin, homocysteine and C-reactive protein (CRP). Dietary intakes, body weights, blood pressure, hunger ratings, and gastrointestinal symptoms were measured at baseline and 6 weeks. Results: The only difference between treatments in lipid outcomes at week 6 was a reduction of the cholesterol/HDL ratio in the low-MW group and a small increase in the high-MW group. No changes were found in blood pressure, glucose, insulin, and gastrointestinal symptoms. Body weight decreased from baseline to 6 weeks in the high-MW group while body weight increased in the low-MW group. Levels of hunger decreased slightly in the low-MW group and decreased significantly in the high-MW group (P = 0.02) Conclusion: Overall, supplementation with isolated barley β-glucans of different molecular weights had small effects on cardiovascular disease markers. Molecular weight of the barley fiber did alter effects on body weight with the high-MW fiber significantly decreasing body weight.
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U2 - 10.1080/07315724.2008.10719722
DO - 10.1080/07315724.2008.10719722
M3 - Article
C2 - 18838533
AN - SCOPUS:58149382866
SN - 0731-5724
VL - 27
SP - 434
EP - 440
JO - Journal of the American College of Nutrition
JF - Journal of the American College of Nutrition
IS - 3
ER -