PINCH-1 expression during early avian embryogenesis: Implications for neural crest and heart development

Brad J. Martinsen, Ann N. Neumann, Allison J. Frasier, Clare V.H. Baker, Catherine E. Krull, Jamie L Lohr

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The invasion of the cardiac neural crest (CNC) into the outflow tract (OFT) and subsequent OFT septation are critical events during vertebrate heart development. We previously had performed four modified differential display (DD) screens in the chick embryo to identify genes that may be involved in CNC and heart development. Full-length sequence of one of the DD clones has been obtained and identified as chick PINCH-1. This particularly interesting new cysteine-histidine-rich protein contains five protein-binding LIM domains (five double zinc fingers), a nuclear localization signal, and a nuclear export signal, allowing it to participate in integrin and growth factor signaling and possibly act as a transcription factor. We show here for the first time that chick PINCH-1 is expressed in neural crest cells, both in the neural fold and cardiac OFT, and is also expressed in mesoderm derived-structures, including the myocardium, during avian embryogenesis. The normal expression pattern and overexpression in neural crest cell explants suggest that PINCH-1 may be a regulator of neural crest cell adhesion and migration.

Original languageEnglish (US)
Pages (from-to)152-162
Number of pages11
JournalDevelopmental Dynamics
Issue number1
StatePublished - Dec 1 2006


  • Cardiac neural crest
  • Cardiac outflow tract
  • Chick
  • Heart development
  • LIM domain
  • Liver
  • Lung
  • Mesonephros
  • Muscle
  • PINCH-1
  • Vertebrae

Fingerprint Dive into the research topics of 'PINCH-1 expression during early avian embryogenesis: Implications for neural crest and heart development'. Together they form a unique fingerprint.

Cite this