Abstract
Plasmonic nanobubbles, new multifunctional cellular nano-agents, are selectively generated in target cancer cells with a short near-infrared laser pulse. The enhanced cellular specificity and tunable transient nature of plasmonic nanobubbles provide fast, efficient and selective dual therapeutic effects: intracellular delivery of a drug and direct mechanical destruction of cells while sparing normal cells, and reduce drug dose and overcome drug-resistance of cancer cells.
Original language | English (US) |
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Pages (from-to) | 3831-3837 |
Number of pages | 7 |
Journal | Advanced Materials |
Volume | 24 |
Issue number | 28 |
DOIs | |
State | Published - Jul 24 2012 |
Keywords
- Doxil
- cancer
- drug resistance
- gold nanoparticles
- laser
- plasmonic nanobubbles