Platelet antiserum inhibits hypoxic pulmonary vasoconstriction in the dog

E. K. Weir, J. Mlczoch, J. Seavy, J. J. Cohen, R. F. Grover

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The literature suggests that platelets might help mediate the pulmonary vascular pressor response to hypoxia. This study evaluated the hypoxic response in dogs rendered acutely thrombocytopenic by the administration of platelet antiserum. Between 30 and 90 min after the antiserum the pulmonary vasoconstrictor response to hypoxia was virtually abolished, but subsequently returned at a time when the number of circulating platelets remained very low. The prior administration of meclofenamate completely preserved the hypoxic response, though the platelet count still fell precipitously. The authors conclude that circulating platelets are not necessary for hypoxic vasoconstriction. It is possible that the reaction between platelets and antiserum evokes the synthesis of a dilator prostaglandin which might be responsible for the temporary inhibition of the pressor response to hypoxia but this remains to be proven.

Original languageEnglish (US)
Pages (from-to)211-215
Number of pages5
JournalUnknown Journal
Volume41
Issue number2
DOIs
StatePublished - Jan 1 1976

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