TY - JOUR
T1 - Platinum-sensitive recurrence in ovarian cancer
T2 - The role of tumor microenvironment
AU - Chien, Jeremy
AU - Kuang, Rui
AU - Landen, Charles
AU - Shridhar, Viji
PY - 2013
Y1 - 2013
N2 - Despite several advances in the understanding of ovarian cancer pathobiology, in terms of driver genetic alterations in high-grade serous cancer, histologic heterogeneity of epithelial ovarian cancer, cell-of-origin for ovarian cancer, the survival rate from ovarian cancer is disappointingly low when compared to that of breast or prostate cancer. One of the factors contributing to the poor survival rate from ovarian cancer is the development of chemotherapy resistance following several rounds of chemotherapy. Although unicellular drug resistance mechanisms contribute to chemotherapy resistance, tumor microenvironment and the extracellular matrix (ECM), in particular, is emerging as a significant determinant of a tumor's response to chemotherapy. In this review, we discuss the potential role of the tumor microenvironment in ovarian cancer recurrence and resistance to chemotherapy. Finally, we propose an alternative view of platinum-sensitive recurrence to describe a potential role of the ECM in the process.
AB - Despite several advances in the understanding of ovarian cancer pathobiology, in terms of driver genetic alterations in high-grade serous cancer, histologic heterogeneity of epithelial ovarian cancer, cell-of-origin for ovarian cancer, the survival rate from ovarian cancer is disappointingly low when compared to that of breast or prostate cancer. One of the factors contributing to the poor survival rate from ovarian cancer is the development of chemotherapy resistance following several rounds of chemotherapy. Although unicellular drug resistance mechanisms contribute to chemotherapy resistance, tumor microenvironment and the extracellular matrix (ECM), in particular, is emerging as a significant determinant of a tumor's response to chemotherapy. In this review, we discuss the potential role of the tumor microenvironment in ovarian cancer recurrence and resistance to chemotherapy. Finally, we propose an alternative view of platinum-sensitive recurrence to describe a potential role of the ECM in the process.
KW - Cancer stem cell
KW - Extracellular matrix
KW - Ovarian cancer
KW - Platinum resistance
KW - Platinum-sensitive recurrence
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U2 - 10.3389/fonc.2013.00251
DO - 10.3389/fonc.2013.00251
M3 - Article
AN - SCOPUS:84888065590
SN - 2234-943X
VL - 3 SEP
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - Article 251
ER -