Polarity-independent effects of tDCS on paired associative stimulation-induced plasticity

Hanna Faber, Alexander Opitz, Florian Müller-Dahlhaus, Ulf Ziemann

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background Transcranial direct current stimulation (tDCS) can polarize the cortex of the human brain. Objective/Hypothesis We sought to verify the hypothesis that posterior-anterior (PA) but not anterior-posterior (AP) tDCS of primary motor cortex (M1) produces cooperative effects with corticospinal plasticity induced by paired associative stimulation of the supplementary motor area (SMA) to M1 projection (PASSMA→M1) in a highly controlled experimental design. Methods Three experimental conditions were tested in a double-blinded, randomized crossover design in 15 healthy adults: Navigated PASSMA→M1 during PA-tDCS (35 cm2 electrodes, anode 3 cm posterior to M1 hand area, cathode over contralateral frontopolar cortex, 1 mA, 2 × 5 min) or AP-tDCS (reversed polarity), or sham-tDCS. Effects were analyzed over 120 min post-intervention by changes of motor evoked potential (MEP) amplitude in a hand muscle. Results There was no significant effect of tDCS on PASSMA→M1 induced plasticity in the repeated-measures ANOVA. However, post-hoc within-subject contrasts revealed a significant tDCS with PASSMA→M1 interaction. This was explained by PA-tDCS and AP-tDCS modifying the PASSMA→M1 effect into the same direction in 13/15 subjects (87%, p = 0.004 for deviation from equality). Sizes of the PA-tDCS and AP-tDCS effects were correlated (rs = 0.53, p = 0.044). A control experiment demonstrated that PA-tDCS and AP-tDCS alone (without PASSMA→M1) had no effect on MEP amplitude. Conclusions Data point to unidirectional tDCS effects on PASSMA→M1 induced plasticity irrespective of tDCS polarity, in contrast to our hypothesis. We propose that radial symmetry of cortical columns, gyral geometry of motor cortex, and cooperativity of plasticity induction can explain the findings.

Original languageEnglish (US)
Pages (from-to)1061-1069
Number of pages9
JournalBrain Stimulation
Volume10
Issue number6
DOIs
StatePublished - Nov 2017

Bibliographical note

Funding Information:
This study was supported by a grant from the German Research Foundation to UZ ( ZI 542/7-1 ). We thank Prof. Peter Martus (Institute for Clinical Epidemiology and Applied Biometry, University of Tübingen) for statistical advice.

Funding Information:
This study was supported by a grant from the German Research Foundation to UZ (ZI 542/7-1). We thank Prof. Peter Martus (Institute for Clinical Epidemiology and Applied Biometry, University of T?bingen) for statistical advice.

Publisher Copyright:
© 2017 Elsevier Inc.

Keywords

  • Human motor cortex
  • Paired associative stimulation
  • Plasticity
  • Polarization
  • Supplementary motor area
  • Transcranial direct current stimulation

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