Polymersomes: Tough vesicles made from diblock copolymers

Bohdana M. Discher, You Yeon Won, David S. Ege, James C M Lee, Frank S. Bates, Dennis E. Discher, Daniel A. Hammer

Research output: Contribution to journalArticlepeer-review

2083 Scopus citations

Abstract

Vesicles were made from amphiphilic diblock copolymers and characterized by micromanipulation. The average molecular weight of the specific polymer studied, polyethyleneoxide-polyethylethylene (EO40-EE37), is several times greater than that of typical phospholipids in natural membranes. Both the membrane bending and area expansion moduli of electroformed polymersomes (polymer-based liposomes) fell within the range of lipid membrane measurements, but the giant polymersomes proved to be almost an order of magnitude tougher and sustained far greater areal strain before rupture. The polymersome membrane was also at least 10 times less permeable to water than common phospholipid bilayers. The results suggest a new class of synthetic thin-shelled capsules based on block copolymer chemistry.

Original languageEnglish (US)
Pages (from-to)1143-1146
Number of pages4
JournalScience
Volume284
Issue number5417
DOIs
StatePublished - May 14 1999

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