TY - JOUR
T1 - Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels
AU - Carlson, Christopher S.
AU - Aldred, Shelley Force
AU - Lee, Philip K.
AU - Tracy, Russell P.
AU - Schwartz, Stephen M.
AU - Rieder, Mark
AU - Liu, Kiang
AU - Williams, O. Dale
AU - Iribarren, Carlos
AU - Lewis, E. Cora
AU - Fornage, Myriam
AU - Boerwinkle, Eric
AU - Gross, Myron
AU - Jaquish, Cashell
AU - Nickerson, Deborah A.
AU - Myers, Richard M.
AU - Siscovick, David S.
AU - Reiner, Alexander P.
N1 - Funding Information:
This work was supported by Inflammatory Genomics and Atherosclerosis Prevention ancillary CARDIA grant HL71017 (to D.S.), by CARDIA contracts N01-HC-95095, N01-HC-48047, N01-HC-48048, N01-HC-48049, N01-HC-48050, N01-HC-45134, and N01-HC-05187 from NHLBI, and by NHLBI Program for Genomic Applications grants HL66682 and HL66642 (to D.N. and M.R.).
PY - 2005/7
Y1 - 2005/7
N2 - Elevated plasma levels of C-reactive protein (CRP), an inflammation- sensitive marker, have emerged as an important predictor of future cardiovascular disease and metabolic abnormalities in apparently healthy men and women. Here, we performed a systematic survey of common nucleotide variation across the genomic region encompassing the CRP gene locus. Of the common single-nucleotide polymorphisms (SNPs) identified, several in the CRP promoter region are strongly associated with CRP levels in a large cohort study of cardiovascular risk in European American and African American young adults. We also demonstrate the functional importance of these SNPs in vitro.
AB - Elevated plasma levels of C-reactive protein (CRP), an inflammation- sensitive marker, have emerged as an important predictor of future cardiovascular disease and metabolic abnormalities in apparently healthy men and women. Here, we performed a systematic survey of common nucleotide variation across the genomic region encompassing the CRP gene locus. Of the common single-nucleotide polymorphisms (SNPs) identified, several in the CRP promoter region are strongly associated with CRP levels in a large cohort study of cardiovascular risk in European American and African American young adults. We also demonstrate the functional importance of these SNPs in vitro.
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U2 - 10.1086/431366
DO - 10.1086/431366
M3 - Article
C2 - 15897982
AN - SCOPUS:20544459972
SN - 0002-9297
VL - 77
SP - 64
EP - 77
JO - American Journal of Human Genetics
JF - American Journal of Human Genetics
IS - 1
ER -
