Elevated plasma levels of C-reactive protein (CRP), an inflammation- sensitive marker, have emerged as an important predictor of future cardiovascular disease and metabolic abnormalities in apparently healthy men and women. Here, we performed a systematic survey of common nucleotide variation across the genomic region encompassing the CRP gene locus. Of the common single-nucleotide polymorphisms (SNPs) identified, several in the CRP promoter region are strongly associated with CRP levels in a large cohort study of cardiovascular risk in European American and African American young adults. We also demonstrate the functional importance of these SNPs in vitro.
Bibliographical noteFunding Information:
This work was supported by Inflammatory Genomics and Atherosclerosis Prevention ancillary CARDIA grant HL71017 (to D.S.), by CARDIA contracts N01-HC-95095, N01-HC-48047, N01-HC-48048, N01-HC-48049, N01-HC-48050, N01-HC-45134, and N01-HC-05187 from NHLBI, and by NHLBI Program for Genomic Applications grants HL66682 and HL66642 (to D.N. and M.R.).