Ponapensin, a cyclopenta[bc]benzopyran with potent NF-κB inhibitory activity from Aglaia ponapensis

Angela A. Salim; Alison D. Pawlus; Hee Byung Chai; Norman R. Farnsworth; A. Douglas Kinghorn; Esperanza J. Carcache-Blanco

doi:10.1016/j.bmcl.2006.09.084

Ponapensin, a cyclopenta[bc]benzopyran with potent NF-κB inhibitory activity from Aglaia ponapensis

Angela A. Salim, Alison D. Pawlus, Hee Byung Chai, Norman R. Farnsworth, A. Douglas Kinghorn, Esperanza J. Carcache-Blanco

Horticultural Science

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Two new compounds, a cyclopenta[bc]benzopyran, ponapensin (1), and an aglaialactone, 5,6-desmethylenedioxy-5-methoxy-aglalactone (2), together with nine known compounds were isolated from the CHCl₃ soluble extract of the leaves and twigs of Aglaia ponapensis. Their structures were established by spectroscopic data interpretation. Ponapensin (1) exhibited significant NF-κB inhibitory activity in an Elisa assay, and was found to be more potent than the positive control rocaglamide. All of the compounds isolated were also tested in a panel of human cancer cell lines, with the known sterol E-volkendousin (3) and methyl rocaglate (aglafoline) found to be the only active substances.

Original language	English (US)
Pages (from-to)	109-112
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2006.09.084
State	Published - Jan 1 2007

Bibliographical note

Funding Information:
This investigation was supported by a new faculty start up package to E. J. C. -B. and, in part, by Grant U19-CA52956 from NCI/NIH (A. D. K.). We thank Dr. Y. Sagawa and S. F. Glassman, for the collection and identification of the plant material, respectively, with financial support from the NCI. We also thank Mr. J. Fowble, College of Pharmacy, The Ohio State University, for facilitating the running of the 400 MHz NMR instrument, and Dr. Christopher M. Haddad and Ms. Susan Fletcher, Department of Chemistry, The Ohio State University, for the mass spectrometric data.

Keywords

Aglaia ponapensis
Cyclopenta[bc]benzopyran
NF-κB
Ponapensin

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Ponapensin, a cyclopenta[bc]benzopyran with potent NF-κB inhibitory activity from Aglaia ponapensis",

abstract = "Two new compounds, a cyclopenta[bc]benzopyran, ponapensin (1), and an aglaialactone, 5,6-desmethylenedioxy-5-methoxy-aglalactone (2), together with nine known compounds were isolated from the CHCl3 soluble extract of the leaves and twigs of Aglaia ponapensis. Their structures were established by spectroscopic data interpretation. Ponapensin (1) exhibited significant NF-κB inhibitory activity in an Elisa assay, and was found to be more potent than the positive control rocaglamide. All of the compounds isolated were also tested in a panel of human cancer cell lines, with the known sterol E-volkendousin (3) and methyl rocaglate (aglafoline) found to be the only active substances.",

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Ponapensin, a cyclopenta[bc]benzopyran with potent NF-κB inhibitory activity from Aglaia ponapensis

Abstract

Bibliographical note

Keywords

UN SDGs

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