Possible regulatory role of dynorphin-(1-13) on narcotic-induced changes in naloxone efficacy

F. Cankat Tulunay; Min Feng Jen; Jaw Kang Chang; Horace H. Loh; Nancy M. Lee

doi:10.1016/0014-2999(81)90506-9

Possible regulatory role of dynorphin-(1-13) on narcotic-induced changes in naloxone efficacy

F. Cankat Tulunay, Min Feng Jen, Jaw Kang Chang, Horace H. Loh, Nancy M. Lee

Pharmacology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Pretreatment of mice with a single injection of morphine, β-endorphin, Leu-enkephalin, FK33824 or [D-Ala²-D-Leu⁵]enkephalin, for 3 h increased the ability of naloxone to antagonize the analgesic effects of morphine. However, dynorphin-(1-13) can only antagonize morphine. β-endorphin or Leu-enkephalin induced increased naloxone efficacy but not FK33824 or [D-Ala²-D-Leu²]enkephalin. Dynorphin itself can also increase naloxone efficacy when treated alone. However, this effect can be prevented when animals are pretreated with dynorphin and naloxone together.

Original language	English (US)
Pages (from-to)	235-239
Number of pages	5
Journal	European Journal of Pharmacology
Volume	76
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-2999(81)90506-9
State	Published - Dec 3 1981

Bibliographical note

Funding Information:
Supported in part by NIDA grant No. DA-02643. The authors thank Dr. Andrew P. Smith for his editorial assistance.

Keywords

Analgesia
Dynorhin-(1-13)
Enkephalins
Morphine
Naloxone
β-Endorphin

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title = "Possible regulatory role of dynorphin-(1-13) on narcotic-induced changes in naloxone efficacy",

abstract = "Pretreatment of mice with a single injection of morphine, β-endorphin, Leu-enkephalin, FK33824 or [D-Ala2-D-Leu5]enkephalin, for 3 h increased the ability of naloxone to antagonize the analgesic effects of morphine. However, dynorphin-(1-13) can only antagonize morphine. β-endorphin or Leu-enkephalin induced increased naloxone efficacy but not FK33824 or [D-Ala2-D-Leu2]enkephalin. Dynorphin itself can also increase naloxone efficacy when treated alone. However, this effect can be prevented when animals are pretreated with dynorphin and naloxone together.",

keywords = "Analgesia, Dynorhin-(1-13), Enkephalins, Morphine, Naloxone, β-Endorphin",

author = "Tulunay, {F. Cankat} and Jen, {Min Feng} and Chang, {Jaw Kang} and Loh, {Horace H.} and Lee, {Nancy M.}",

note = "Funding Information: Supported in part by NIDA grant No. DA-02643. The authors thank Dr. Andrew P. Smith for his editorial assistance.",

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AU - Jen, Min Feng

AU - Chang, Jaw Kang

AU - Loh, Horace H.

AU - Lee, Nancy M.

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AB - Pretreatment of mice with a single injection of morphine, β-endorphin, Leu-enkephalin, FK33824 or [D-Ala2-D-Leu5]enkephalin, for 3 h increased the ability of naloxone to antagonize the analgesic effects of morphine. However, dynorphin-(1-13) can only antagonize morphine. β-endorphin or Leu-enkephalin induced increased naloxone efficacy but not FK33824 or [D-Ala2-D-Leu2]enkephalin. Dynorphin itself can also increase naloxone efficacy when treated alone. However, this effect can be prevented when animals are pretreated with dynorphin and naloxone together.

KW - Analgesia

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KW - Enkephalins

KW - Morphine

KW - Naloxone

KW - β-Endorphin

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Possible regulatory role of dynorphin-(1-13) on narcotic-induced changes in naloxone efficacy

Abstract

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Keywords

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