Possible regulatory role of dynorphin-(1-13) on narcotic-induced changes in naloxone efficacy

F. Cankat Tulunay, Min Feng Jen, Jaw Kang Chang, Horace H. Loh, Nancy M. Lee

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Pretreatment of mice with a single injection of morphine, β-endorphin, Leu-enkephalin, FK33824 or [D-Ala2-D-Leu5]enkephalin, for 3 h increased the ability of naloxone to antagonize the analgesic effects of morphine. However, dynorphin-(1-13) can only antagonize morphine. β-endorphin or Leu-enkephalin induced increased naloxone efficacy but not FK33824 or [D-Ala2-D-Leu2]enkephalin. Dynorphin itself can also increase naloxone efficacy when treated alone. However, this effect can be prevented when animals are pretreated with dynorphin and naloxone together.

Original languageEnglish (US)
Pages (from-to)235-239
Number of pages5
JournalEuropean Journal of Pharmacology
Volume76
Issue number2-3
DOIs
StatePublished - Dec 3 1981

Bibliographical note

Funding Information:
Supported in part by NIDA grant No. DA-02643. The authors thank Dr. Andrew P. Smith for his editorial assistance.

Keywords

  • Analgesia
  • Dynorhin-(1-13)
  • Enkephalins
  • Morphine
  • Naloxone
  • β-Endorphin

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