Post-transcriptional regulation of cytokine signaling during inflammatory responses

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Cytokines serve essential roles in cell to cell communication during development, maintenance of homeostasis, and responses to external stimuli. The expression of cytokines and the signals transmitted by cytokines to target cells need to be tightly regulated at several levels, including transcriptional and post-transcriptional levels. We briefly summarize the role of post-transcriptional mechanisms in coordinating the regulation of cytokine signaling during inflammatory responses, with an emphasis on AU-rich elements (AREs) and GU-rich elements (GREs). AREs and GREs work in concert to coordinate networks of cytokine signaling. The precise regulation of cytokine signaling is particularly important because its dysregulation can be a contributing factor for human diseases, including autoimmune diseases and cancer.

Original languageEnglish (US)
Title of host publicationPost-Transcriptional Mechanisms in Endocrine Regulation
PublisherSpringer International Publishing
Pages55-70
Number of pages16
ISBN (Electronic)9783319251240
ISBN (Print)9783319251226
DOIs
StatePublished - Jan 1 2015

Keywords

  • AU-rich element: ARE
  • CELF1, ELAVL1, ZFP36
  • Combinatorial control
  • Competitive binding
  • Endoribonuclease
  • GU-rich element: GRE
  • mRNA degradation
  • mRNA protein complex: mRNP
  • mRNA stabilization

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