Posterior staphyloma is typically associated with myopic degeneration and has not been recognized as a cause of reduced visual acuity in albinism. We report 3 cases of posterior staphyloma, each with oculocutaneous albinism (OCA) defined by phenotype and genotype. Two cases are biological sisters with OCA type 2; one was myopic and the other was hyperopic. The third case involves a man with OCA associated with Hermansky-Pudlak syndrome (HPS-5). Staphyloma may be another cause of reduced visual acuity in albinism, particularly with increasing age. It may occur in association with myopia or hyperopia.
Bibliographical noteFunding Information:
Supported, in part, by an unrestricted grant from Research to Prevent Blindness, Inc. , New York, NY, to the Department of Ophthalmology and Visual Neurosciences at the University of Minnesota, Minneapolis, MN. This project was also partially supported by NIH grants UL1TR000427 and NIH 1U01HG006389-01 .
© 2015 American Association for Pediatric Ophthalmology and Strabismus.