Postprandial endothelial function, inflammation, and oxidative stress in obese children and adolescents

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Abstract

Most studies in adults suggest that acute glucose consumption induces a transient impairment in endothelial function. We hypothesized that obese youth would demonstrate reduced endothelial function and increased inflammation and oxidative stress following acute glucose ingestion and that transient elevations in plasma glucose would correlate with endothelial dysfunction, inflammation, and oxidative stress. Thirty-four obese (BMI 95th percentile) children and adolescents (age 12.4 2.6 years; BMI = 37.9 6.7kg/m 2; 50% females) underwent measurement of endothelial function (reactive hyperemic index (RHI)), glucose, insulin, C-reactive protein (CRP), interleukin-6 (IL-6), circulating oxidized low-density lipoprotein (oxLDL), and myeloperoxidase (MPO) in a fasting state and at 1- and 2-h following glucose ingestion. Repeated measures ANOVA with Tukey post-tests and Pearson correlations were performed. Glucose and insulin levels significantly increased at 1- and 2-h (all P values 0.001). Compared to baseline, there were no statistically significant differences in 1- and 2-h RHI, CRP, IL-6, and oxLDL. However, MPO significantly decreased at the 1- (P <0.05) and 2-h (P 0.001) time points. At the 1-h time point, glucose level was significantly inversely correlated with RHI (r = 0.40, P <0.05) and at the 2-h time point, glucose level was positively correlated with MPO (r = 0.40, P <0.05). An acute oral glucose load does not reduce endothelial function or increase levels of inflammation or oxidative stress in obese youth. However, associations of postprandial hyperglycemia with endothelial function and oxidative stress may have implications for individuals with impaired glucose tolerance or frank type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)1279-1283
Number of pages5
JournalObesity
Volume19
Issue number6
DOIs
StatePublished - Jun 2011

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