Posttransplant adenoviral enteropathy in patients with small bowel transplantation

Oyedele A. Adeyi, Parmjeet A. Randhawa, Michael A. Nalesnik, Erin R. Ochoa, Kareem M. Abu-Elmagd, Anthony J. Demetris, Tong Wu

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Transplant patients on immunosuppression represent a risk group for opportunistic infections, including adenoviral infections. The clinical and histopathologic findings of posttransplant adenoviral enteropathy in 3 adult intestinal transplant patients are described. The histopathologic pitfalls for the differential diagnosis between intestinal adenoviral enteropathy and acute rejection are discussed. Adenoviral enteropathy is an opportunistic infection that may follow aggressive treatment for small bowel allograft rejection, but which may require no specific treatment. It is associated with mild mixed inflammation in the lamina propria and slight increase of crypt apoptosis, resembling low-grade acute rejection. The identification of characteristic viral inclusions in the surface or crypt epithelium points to the diagnosis of adenoviral enteropathy, in spite of the increased crypt apoptosis.

Original languageEnglish (US)
Pages (from-to)703-705
Number of pages3
JournalArchives of Pathology and Laboratory Medicine
Volume132
Issue number4
StatePublished - Apr 1 2008
Externally publishedYes

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