Potency of the N3im-methyl analog of TRH in the induction of shaking movements in the rat

Eddie Wei, Horace Loh, E. Leong Way

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The relative potencies of TRH analogs in provoking a shaking response in rats were determined. Bilateral administration of 0.011-2.0 μg TRH analog into the periaqueductal-fourth ventricular spaces of the barbiturate-anesthetized rat showed that N3im-methyl TRH was approximately 10X more potent than TRH, wherease N1im-methyl TRH was approximately 10X less potent than TRH. These results indicate that the potencies of the TRH analogs in inducing shaking parallel their thyrotropin-releasing activities.

Original languageEnglish (US)
Pages (from-to)227-229
Number of pages3
JournalEuropean Journal of Pharmacology
Issue number1
StatePublished - Mar 1976


  • N-and N-methyl TRH
  • Shaking in rats
  • Thyrotropin-releasing hormone (TRH)


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