Potency of the N3im-methyl analog of TRH in the induction of shaking movements in the rat

Eddie Wei; Horace Loh; E. Leong Way

doi:10.1016/0014-2999(76)90276-4

Potency of the N^3im-methyl analog of TRH in the induction of shaking movements in the rat

Eddie Wei, Horace Loh, E. Leong Way

Pharmacology

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20 Scopus citations

Abstract

The relative potencies of TRH analogs in provoking a shaking response in rats were determined. Bilateral administration of 0.011-2.0 μg TRH analog into the periaqueductal-fourth ventricular spaces of the barbiturate-anesthetized rat showed that N^3im-methyl TRH was approximately 10X more potent than TRH, wherease N^1im-methyl TRH was approximately 10X less potent than TRH. These results indicate that the potencies of the TRH analogs in inducing shaking parallel their thyrotropin-releasing activities.

Original language	English (US)
Pages (from-to)	227-229
Number of pages	3
Journal	European Journal of Pharmacology
Volume	36
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(76)90276-4
State	Published - Mar 1976

Keywords

N-and N-methyl TRH
Shaking in rats
Thyrotropin-releasing hormone (TRH)

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title = "Potency of the N3im-methyl analog of TRH in the induction of shaking movements in the rat",

abstract = "The relative potencies of TRH analogs in provoking a shaking response in rats were determined. Bilateral administration of 0.011-2.0 μg TRH analog into the periaqueductal-fourth ventricular spaces of the barbiturate-anesthetized rat showed that N3im-methyl TRH was approximately 10X more potent than TRH, wherease N1im-methyl TRH was approximately 10X less potent than TRH. These results indicate that the potencies of the TRH analogs in inducing shaking parallel their thyrotropin-releasing activities.",

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N2 - The relative potencies of TRH analogs in provoking a shaking response in rats were determined. Bilateral administration of 0.011-2.0 μg TRH analog into the periaqueductal-fourth ventricular spaces of the barbiturate-anesthetized rat showed that N3im-methyl TRH was approximately 10X more potent than TRH, wherease N1im-methyl TRH was approximately 10X less potent than TRH. These results indicate that the potencies of the TRH analogs in inducing shaking parallel their thyrotropin-releasing activities.

AB - The relative potencies of TRH analogs in provoking a shaking response in rats were determined. Bilateral administration of 0.011-2.0 μg TRH analog into the periaqueductal-fourth ventricular spaces of the barbiturate-anesthetized rat showed that N3im-methyl TRH was approximately 10X more potent than TRH, wherease N1im-methyl TRH was approximately 10X less potent than TRH. These results indicate that the potencies of the TRH analogs in inducing shaking parallel their thyrotropin-releasing activities.

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KW - Shaking in rats

KW - Thyrotropin-releasing hormone (TRH)

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