Potent inhibition of leukotriene (LT) B4 release from human polymorphonuclear leukocytes (PMN) by the PGE1-analogue OP-1206

P. Ney; G. Hecker; H. Schroder; K. Schror

Potent inhibition of leukotriene (LT) B4 release from human polymorphonuclear leukocytes (PMN) by the PGE1-analogue OP-1206

P. Ney, G. Hecker, H. Schroder, K. Schror

Pharmaceutics

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4 Scopus citations

Abstract

The present study investigates the inhibitory action of the PGE₁-analogue OP-1206 on stimulated LTB₄ release from human PMN. In comparison with PGE₂, PGE₁ and iloprost,OP-1206 was equipotent to PGE₂ and PGE₁ as inhibitor of PAF (3 μM) and FMLP (10 μM) induced LTB₄ release even in the presence of exogenous arachidonic acid (10 μM). Iloprost was ineffective in this assay at a concentration of 10 μM. The data together with earlier observations suggest that E-type prostaglandins are potent inhibitors of receptor-mediated PMN activation and that these compounds may be valuable for prevention of PMN-associated tissue damage.

Original language	English (US)
Journal	Biomedica Biochimica Acta
Volume	47
Issue number	10-11
State	Published - Dec 1 1988

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AU - Ney, P.

AU - Hecker, G.

AU - Schroder, H.

AU - Schror, K.

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N2 - The present study investigates the inhibitory action of the PGE1-analogue OP-1206 on stimulated LTB4 release from human PMN. In comparison with PGE2, PGE1 and iloprost,OP-1206 was equipotent to PGE2 and PGE1 as inhibitor of PAF (3 μM) and FMLP (10 μM) induced LTB4 release even in the presence of exogenous arachidonic acid (10 μM). Iloprost was ineffective in this assay at a concentration of 10 μM. The data together with earlier observations suggest that E-type prostaglandins are potent inhibitors of receptor-mediated PMN activation and that these compounds may be valuable for prevention of PMN-associated tissue damage.

AB - The present study investigates the inhibitory action of the PGE1-analogue OP-1206 on stimulated LTB4 release from human PMN. In comparison with PGE2, PGE1 and iloprost,OP-1206 was equipotent to PGE2 and PGE1 as inhibitor of PAF (3 μM) and FMLP (10 μM) induced LTB4 release even in the presence of exogenous arachidonic acid (10 μM). Iloprost was ineffective in this assay at a concentration of 10 μM. The data together with earlier observations suggest that E-type prostaglandins are potent inhibitors of receptor-mediated PMN activation and that these compounds may be valuable for prevention of PMN-associated tissue damage.

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Potent inhibition of leukotriene (LT) B4 release from human polymorphonuclear leukocytes (PMN) by the PGE1-analogue OP-1206

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