Potential linkage disequilibrium between schizophrenia and locus D22S278 on the long arm of chromosome 22

H. W. Moises, L. Yang, T. Li, B. Havsteen, R. Fimmers, M. P. Baur, X. Liu, I. I. Gottesman

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52 Scopus citations

Abstract

Locus D22S278 at 22q12 has been implicated in schizophrenia by sib-pair analysis. In order to replicate these results, we performed the transmission test for linkage disequilibrium (TDT) in 113 unrelated schizophrenic patients and their 226 parents. Evidence for potential linkage disequilibrium was obtained between schizophrenia and allele 243 of the marker AFM 182xd12 at the locus D22S278 (P = 0.02). The results of our study suggest a detectable oligogenic gene in a multigene system for schizophrenia closely linked to D22S278 on the long arm of chromosome 22. If confirmed by others, this finding could lead to the identification of a schizophrenia susceptibility gene.

Original languageEnglish (US)
Pages (from-to)465-467
Number of pages3
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume60
Issue number5
DOIs
StatePublished - 1995

Keywords

  • chromosome 22
  • genetics
  • linkage disequilibrium
  • schizophrenia

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