Powder properties and compaction parameters that influence punch sticking propensity of pharmaceuticals

Shubhajit Paul, Lisa J. Taylor, Brendan Murphy, Joseph F. Krzyzaniak, Neil Dawson, Matthew P. Mullarney, Paul Meenan, Changquan Calvin Sun

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Punch sticking is a frequently occurring problem that challenges successful tablet manufacturing. A mechanistic understanding of the punch sticking phenomenon facilitates the design of effective strategies to solve punch sticking problems of a drug. The first step in this effort is to identify process parameters and particle properties that can profoundly affect sticking performance. This work was aimed at elucidating the key material properties and compaction parameters that influence punch sticking by statistically analyzing punch sticking data of 24 chemically diverse compounds obtained using a set of tooling with removable upper punch tip. Partial least square (PLS) analysis of the data revealed that particle surface area and tablet tensile strength are the most significant factors attributed to punch sticking. Die-wall pressure, ejection force, and take-off force also correlate with sticking, but to a lesser extent.

Original languageEnglish (US)
Pages (from-to)374-383
Number of pages10
JournalInternational journal of pharmaceutics
Volume521
Issue number1-2
DOIs
StatePublished - Apr 15 2017

Keywords

  • Linear regression
  • PLS analysis
  • Powder compaction
  • Sticking
  • Surface area
  • Tensile strength

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