Practical syntheses of the C12-C21 epothilone subunit via catalytic asymmetric reductions: Itsuno-Corey oxazaborolidine reduction and asymmetric Noyori hydrogenation

Emily A. Reiff, Sajiv K. Nair, B. S. Narayan Reddy, Jun Inagaki, John T. Henri, Jack F. Greiner, Gunda I. Georg

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Two practical catalytic asymmetric reductions to introduce the epothilone C15 stereocenter are described (Itsuno-Corey reduction and Noyori hydrogenation).

Original languageEnglish (US)
Pages (from-to)5845-5847
Number of pages3
JournalTetrahedron Letters
Volume45
Issue number30
DOIs
StatePublished - Jul 19 2004

Bibliographical note

Funding Information:
We gratefully acknowledge financial support from the National Institutes of Health's National Cancer Institute (NCI CA79641) and the General Research Fund at the University of Kansas. E.A.R. acknowledges the NIH training grant (NIH-GM-07775), and the American Foundation for Pharmaceutical Education for fellowships. E.A.R. and J.I. acknowledge the Department of Defense (DAMD 17-00-1-0303) for fellowship support.

Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.

Keywords

  • Antitumor agents
  • Asymmetric catalysis
  • Epothilones
  • Itsuno-Corey reduction
  • Noyori reduction

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