Abstract
Two practical catalytic asymmetric reductions to introduce the epothilone C15 stereocenter are described (Itsuno-Corey reduction and Noyori hydrogenation).
Original language | English (US) |
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Pages (from-to) | 5845-5847 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 45 |
Issue number | 30 |
DOIs | |
State | Published - Jul 19 2004 |
Bibliographical note
Funding Information:We gratefully acknowledge financial support from the National Institutes of Health's National Cancer Institute (NCI CA79641) and the General Research Fund at the University of Kansas. E.A.R. acknowledges the NIH training grant (NIH-GM-07775), and the American Foundation for Pharmaceutical Education for fellowships. E.A.R. and J.I. acknowledge the Department of Defense (DAMD 17-00-1-0303) for fellowship support.
Keywords
- Antitumor agents
- Asymmetric catalysis
- Epothilones
- Itsuno-Corey reduction
- Noyori reduction