Predicting Outcomes After Distal Radius Fracture: A 24-Center International Clinical Trial of Older Adults

WRIST Group

doi:10.1016/j.jhsa.2019.05.016

Predicting Outcomes After Distal Radius Fracture: A 24-Center International Clinical Trial of Older Adults

WRIST Group

Orthopaedic Surgery

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Purpose: Current evidence on predictors of outcomes after distal radius fracture is often based on retrospective analyses or may be confounded by fracture type. Using data from the Wrist and Radius Injury Surgical Trial (WRIST), a 24-site randomized study of distal radius fracture treatment, in which all fractures are severe enough to warrant surgery, we set out to perform a secondary data analysis to explore predictors of better or worse hand outcomes. Methods: The primary outcome measure was the Michigan Hand Outcomes Questionnaire (MHQ) summary score 12 months after treatment. We used a regression tree analysis with recursive partitioning to identify subgroups of participants who experienced similar outcomes (ie, MHQ score) and to determine which baseline or treatment factors they had in common. Results: Factors most predictive of 12-month MHQ score were pain at enrollment, education, age, and number of comorbidities. Specifically, participants who had a high school education or less and also reported severe pain had the lowest MHQ scores. Conversely, participants with less pain and more education and who were age 87 years or younger with one or no comorbid condition had the highest MHQ scores. Treatment type or radiographic measurements assessed on post-reduction films did not affect 12-month outcomes. Conclusions: These results identified patient characteristics that can be used by surgeons to identify subgroups of patients who may experience similar hand outcomes. Type of study/level of evidence: Prognostic III.

Original language	English (US)
Pages (from-to)	762-771
Number of pages	10
Journal	Journal of Hand Surgery
Volume	44
Issue number	9
DOIs	https://doi.org/10.1016/j.jhsa.2019.05.016
State	Published - Sep 2019

Bibliographical note

Funding Information:
Research reported in this publication was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases and the National Institute on Aging of the National Institutes of Health under Award Number R01 AR062066 and by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award Number 2 K24-AR053120-06. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The WRIST Group consists of the following: Michigan Medicine (Coordinating Center): Kevin C. Chung, MD, MS (Principal Investigator); H. Myra Kim, ScD (Study Biostatistician); Steven C. Haase, MD; Jeffrey N. Lawton, MD; John R. Lien, MD; Adeyiza O. Momoh, MD; Kagan Ozer, MD; Erika D. Sears, MD, MS; Jennifer F. Waljee, MD, MPH; Matthew S. Brown, MD; Hoyune E. Cho, MD; Brett F. Michelotti, MD; Sunitha Malay, MPH (Study Coordinator); Melissa J. Shauver, MPH (Study Coordinator). Beth Israel Deaconess Medical Center: Tamara D. Rozental, MD (Co-Investigator); Paul T. Appleton, MD; Edward K. Rodriguez, MD, PhD; Laura N. Deschamps, DO; Lindsay Mattfolk, BA; Katiri Wagner. Brigham and Women's Hospital: Philip Blazar, MD (Co-Investigator); Brandon E. Earp, MD; W. Emerson Floyd; Dexter L. Louie, BS. Duke Health: Fraser J. Leversedge, MD (Co-Investigator); Marc J. Richard, MD; David, S. Ruch, MD; Suzanne Finley, CRC; Cameron Howe, CRC; Maria Manson; Janna Whitfield, BS. Fraser Health Authority: Bertrand H. Perey, MD (Co-Investigator); Kelly Apostle, MD, FRCSC; Dory Boyer, MD, FRCSC; Farhad Moola, MD, FRCSC; Trevor Stone, MD, FRCSC; Darius Viskontas, MD, FRCSC; Mauri Zomar, CCRP; Karyn Moon; Raely Moon. Health Partners Institute for Education and Research: Loree K. Kalliainen, MD, MA (Co-Investigator, now at University of North Carolina Health Care); Christina M. Ward, MD (Co-Investigator); James W. Fletcher, MD; Cherrie A. Heinrich, MD; Katharine S. Pico, MD; Ashish Y. Mahajan, MD; Brian W. Hill, MD; Sandy Vang, BA. Johns Hopkins Medicine: Dawn M. Laporte, MD (Co-Investigator); Erik A. Hasenboehler, MD; Scott D. Lifchez, MD; Greg M. Osgood, MD; Babar Shafiq, MD, MS; Jaimie T. Shores, MD; Vaishali Laljani. Kettering Health Network: H. Brent Bamberger, DO (Co-Investigator); Timothy W. Harman, DO; David W. Martineau, MD; Carla Robinson, PA-C, MPAS; Brandi Palmer, MS, PC, CCRP. London Health Sciences Centre: Ruby Grewal, MD, MS (Co-Investigator); Ken A. Faber, MD; Joy C. MacDermid, PhD (Study Epidemiologist); Kate Kelly, MSc, MPH; Katrina Munro; Joshua I. Vincent, PT, PhD. Massachusetts General Hospital: David Ring, MD, PhD (Co-Investigator, now at University of Texas Health Austin); Jesse B. Jupiter, MD, MA; Abigail Finger, BA; Jillian S. Gruber, MD; Rajesh K. Reddy; Taylor M. Pong; Emily R. Thornton, BSc. Mayo Clinic: David G. Dennison, MD (Co-Investigator); Sanjeev Kakar, MD; Marco Rizzo, MD; Alexander Y. Shin, MD; Tyson L. Scrabeck, CCRP. The MetroHealth System: Kyle Chepla, MD (Co-Investigator); Kevin Malone, MD; Harry A. Hoyen, MD; Blaine Todd Bafus, MD; Roderick B. Jordan, MD; Bram Kaufman, MD; Ali Totonchil, MD; Dana R. Hromyak, BS, RRT; Lisa Humbert, RN. National University of Singapore: Sandeep Sebastin, MCh (Co-Investigator), Sally Tay. Northwell Health: Kate W. Nellans, MD, MPH (Co-Investigator); Sara L. Merwin, MPH. Norton Healthcare: Ethan W. Blackburn, MD (Co-Investigator); Sandra J. Hanlin, APRN, NP-C; Barbara Patterson, BSN, CCRC. OrthoCarolina Research Institute: R. Glenn Gaston, MD (Co-Investigator); R. Christopher Cadderdon, MD; Erika Gordon Gantt, MD; John S. Gaul, MD; Daniel R. Lewis, MD; Bryan J. Loeffler, MD; Lois K. Osier, MD; Paul C. Perlik, MD; W. Alan Ward, MD; Benjamin Connell, BA, CCRC; Pricilla Haug, BA, CCRC; Caleb Michalek, BS, CCRC. Pan Am Clinic/University of Manitoba: Tod A. Clark, MD, MSc, FRCSC(Co-Investigator); Sheila McRae, MSc, PhD. University of Connecticut Health: Jennifer Moriatis Wolf, MD (Co-Investigator, now at University of Chicago Medicine); Craig M. Rodner, MD; Katy Coyle, RN. University of Oklahoma Medicine: Thomas P. Lehman, MD, PT (Co-Investigator); Yuri C. Lansinger, MD; Gavin D. O'Mahony, MD; Kathy Carl, BA, CCRP; Janet Wells. University of Pennsylvania Health System: David J. Bozentka, MD (Co-Investigator); L. Scott Levin, MD; David P. Steinberg, MD; Annamarie D. Horan, PhD; Denise Knox, BS; Kara Napolitano, BS. University of Pittsburgh Medical Center: John Fowler, MD (Co-Investigator); Robert Goitz, MD; Cathy A. Naccarelli; Joelle Tighe. University of Rochester: Warren C. Hammert, MD, DDS (Co-Investigator); Allison W. McIntyre, MPH; Krista L. Noble; Kaili Waldrick. University of Washington Medicine: Jeffery B. Friedrich, MD (Co-Investigator); David Bowman; Angela Wilson. Wake Forest Baptist Health: Zhongyu Li, MD, PhD (Co-Investigator); L. Andrew Koman, MD; Benjamin R. Graves, MD; Beth P. Smith, PhD; Debra Bullard.

Funding Information:
Research reported in this publication was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases and the National Institute on Aging of the National Institutes of Health under Award Number R01 AR062066 and by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award Number 2 K24-AR053120-06 . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Publisher Copyright:
© 2019 American Society for Surgery of the Hand

Keywords

Distal radius fracture
older adults
predictors of outcomes

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10.1016/j.jhsa.2019.05.016

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Full text

Cite this

@article{64ae33ef0aa549da816438ef0dd331b4,

title = "Predicting Outcomes After Distal Radius Fracture: A 24-Center International Clinical Trial of Older Adults",

abstract = "Purpose: Current evidence on predictors of outcomes after distal radius fracture is often based on retrospective analyses or may be confounded by fracture type. Using data from the Wrist and Radius Injury Surgical Trial (WRIST), a 24-site randomized study of distal radius fracture treatment, in which all fractures are severe enough to warrant surgery, we set out to perform a secondary data analysis to explore predictors of better or worse hand outcomes. Methods: The primary outcome measure was the Michigan Hand Outcomes Questionnaire (MHQ) summary score 12 months after treatment. We used a regression tree analysis with recursive partitioning to identify subgroups of participants who experienced similar outcomes (ie, MHQ score) and to determine which baseline or treatment factors they had in common. Results: Factors most predictive of 12-month MHQ score were pain at enrollment, education, age, and number of comorbidities. Specifically, participants who had a high school education or less and also reported severe pain had the lowest MHQ scores. Conversely, participants with less pain and more education and who were age 87 years or younger with one or no comorbid condition had the highest MHQ scores. Treatment type or radiographic measurements assessed on post-reduction films did not affect 12-month outcomes. Conclusions: These results identified patient characteristics that can be used by surgeons to identify subgroups of patients who may experience similar hand outcomes. Type of study/level of evidence: Prognostic III.",

keywords = "Distal radius fracture, older adults, predictors of outcomes",

author = "{WRIST Group} and Chung, {Kevin C.} and Kim, {H. Myra} and Sunitha Malay and Shauver, {Melissa J.} and Haase, {Steven C.} and Lawton, {Jeffrey N.} and Lien, {John R.} and Momoh, {Adeyiza O.} and Kagan Ozer and Sears, {Erika D.} and Waljee, {Jennifer F.} and Brown, {Matthew S.} and Cho, {Hoyune E.} and Michelotti, {Brett F.} and Rozental, {Tamara D.} and Appleton, {Paul T.} and Rodriguez, {Edward K.} and Deschamps, {Laura N.} and Lindsay Mattfolk and Katiri Wagner and Philip Blazar and Earp, {Brandon E.} and Floyd, {W. Emerson} and Louie, {Dexter L.} and Leversedge, {Fraser J.} and Richard, {Marc J.} and Ruch, {David S.} and Suzanne Finley and Cameron Howe and Maria Manson and Janna Whitfield and Perey, {Bertrand H.} and Kelly Apostle and Dory Boyer and Farhad Moola and Trevor Stone and Darius Viskontas and Mauri Zomar and Karyn Moon and Raely Moon and Kalliainen, {Loree K.} and Ward, {Christina M.} and Fletcher, {James W.} and Heinrich, {Cherrie A.} and Pico, {Katharine S.} and Mahajan, {Ashish Y.} and Hill, {Brian W.} and Sandy Vang and Laporte, {Dawn M.} and Hasenboehler, {Erik A.}",

note = "Funding Information: Research reported in this publication was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases and the National Institute on Aging of the National Institutes of Health under Award Number R01 AR062066 and by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award Number 2 K24-AR053120-06. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The WRIST Group consists of the following: Michigan Medicine (Coordinating Center): Kevin C. Chung, MD, MS (Principal Investigator); H. Myra Kim, ScD (Study Biostatistician); Steven C. Haase, MD; Jeffrey N. Lawton, MD; John R. Lien, MD; Adeyiza O. Momoh, MD; Kagan Ozer, MD; Erika D. Sears, MD, MS; Jennifer F. Waljee, MD, MPH; Matthew S. Brown, MD; Hoyune E. Cho, MD; Brett F. Michelotti, MD; Sunitha Malay, MPH (Study Coordinator); Melissa J. Shauver, MPH (Study Coordinator). Beth Israel Deaconess Medical Center: Tamara D. Rozental, MD (Co-Investigator); Paul T. Appleton, MD; Edward K. Rodriguez, MD, PhD; Laura N. Deschamps, DO; Lindsay Mattfolk, BA; Katiri Wagner. Brigham and Women's Hospital: Philip Blazar, MD (Co-Investigator); Brandon E. Earp, MD; W. Emerson Floyd; Dexter L. Louie, BS. Duke Health: Fraser J. Leversedge, MD (Co-Investigator); Marc J. Richard, MD; David, S. Ruch, MD; Suzanne Finley, CRC; Cameron Howe, CRC; Maria Manson; Janna Whitfield, BS. Fraser Health Authority: Bertrand H. Perey, MD (Co-Investigator); Kelly Apostle, MD, FRCSC; Dory Boyer, MD, FRCSC; Farhad Moola, MD, FRCSC; Trevor Stone, MD, FRCSC; Darius Viskontas, MD, FRCSC; Mauri Zomar, CCRP; Karyn Moon; Raely Moon. Health Partners Institute for Education and Research: Loree K. Kalliainen, MD, MA (Co-Investigator, now at University of North Carolina Health Care); Christina M. Ward, MD (Co-Investigator); James W. Fletcher, MD; Cherrie A. Heinrich, MD; Katharine S. Pico, MD; Ashish Y. Mahajan, MD; Brian W. Hill, MD; Sandy Vang, BA. Johns Hopkins Medicine: Dawn M. Laporte, MD (Co-Investigator); Erik A. Hasenboehler, MD; Scott D. Lifchez, MD; Greg M. Osgood, MD; Babar Shafiq, MD, MS; Jaimie T. Shores, MD; Vaishali Laljani. Kettering Health Network: H. Brent Bamberger, DO (Co-Investigator); Timothy W. Harman, DO; David W. Martineau, MD; Carla Robinson, PA-C, MPAS; Brandi Palmer, MS, PC, CCRP. London Health Sciences Centre: Ruby Grewal, MD, MS (Co-Investigator); Ken A. Faber, MD; Joy C. MacDermid, PhD (Study Epidemiologist); Kate Kelly, MSc, MPH; Katrina Munro; Joshua I. Vincent, PT, PhD. Massachusetts General Hospital: David Ring, MD, PhD (Co-Investigator, now at University of Texas Health Austin); Jesse B. Jupiter, MD, MA; Abigail Finger, BA; Jillian S. Gruber, MD; Rajesh K. Reddy; Taylor M. Pong; Emily R. Thornton, BSc. Mayo Clinic: David G. Dennison, MD (Co-Investigator); Sanjeev Kakar, MD; Marco Rizzo, MD; Alexander Y. Shin, MD; Tyson L. Scrabeck, CCRP. The MetroHealth System: Kyle Chepla, MD (Co-Investigator); Kevin Malone, MD; Harry A. Hoyen, MD; Blaine Todd Bafus, MD; Roderick B. Jordan, MD; Bram Kaufman, MD; Ali Totonchil, MD; Dana R. Hromyak, BS, RRT; Lisa Humbert, RN. National University of Singapore: Sandeep Sebastin, MCh (Co-Investigator), Sally Tay. Northwell Health: Kate W. Nellans, MD, MPH (Co-Investigator); Sara L. Merwin, MPH. Norton Healthcare: Ethan W. Blackburn, MD (Co-Investigator); Sandra J. Hanlin, APRN, NP-C; Barbara Patterson, BSN, CCRC. OrthoCarolina Research Institute: R. Glenn Gaston, MD (Co-Investigator); R. Christopher Cadderdon, MD; Erika Gordon Gantt, MD; John S. Gaul, MD; Daniel R. Lewis, MD; Bryan J. Loeffler, MD; Lois K. Osier, MD; Paul C. Perlik, MD; W. Alan Ward, MD; Benjamin Connell, BA, CCRC; Pricilla Haug, BA, CCRC; Caleb Michalek, BS, CCRC. Pan Am Clinic/University of Manitoba: Tod A. Clark, MD, MSc, FRCSC(Co-Investigator); Sheila McRae, MSc, PhD. University of Connecticut Health: Jennifer Moriatis Wolf, MD (Co-Investigator, now at University of Chicago Medicine); Craig M. Rodner, MD; Katy Coyle, RN. University of Oklahoma Medicine: Thomas P. Lehman, MD, PT (Co-Investigator); Yuri C. Lansinger, MD; Gavin D. O'Mahony, MD; Kathy Carl, BA, CCRP; Janet Wells. University of Pennsylvania Health System: David J. Bozentka, MD (Co-Investigator); L. Scott Levin, MD; David P. Steinberg, MD; Annamarie D. Horan, PhD; Denise Knox, BS; Kara Napolitano, BS. University of Pittsburgh Medical Center: John Fowler, MD (Co-Investigator); Robert Goitz, MD; Cathy A. Naccarelli; Joelle Tighe. University of Rochester: Warren C. Hammert, MD, DDS (Co-Investigator); Allison W. McIntyre, MPH; Krista L. Noble; Kaili Waldrick. University of Washington Medicine: Jeffery B. Friedrich, MD (Co-Investigator); David Bowman; Angela Wilson. Wake Forest Baptist Health: Zhongyu Li, MD, PhD (Co-Investigator); L. Andrew Koman, MD; Benjamin R. Graves, MD; Beth P. Smith, PhD; Debra Bullard. Funding Information: Research reported in this publication was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases and the National Institute on Aging of the National Institutes of Health under Award Number R01 AR062066 and by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award Number 2 K24-AR053120-06 . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: {\textcopyright} 2019 American Society for Surgery of the Hand",

year = "2019",

month = sep,

doi = "10.1016/j.jhsa.2019.05.016",

language = "English (US)",

volume = "44",

pages = "762--771",

journal = "Journal of Hand Surgery",

issn = "0363-5023",

publisher = "W.B. Saunders Ltd",

number = "9",

}

TY - JOUR

T1 - Predicting Outcomes After Distal Radius Fracture

T2 - A 24-Center International Clinical Trial of Older Adults

AU - WRIST Group

AU - Chung, Kevin C.

AU - Kim, H. Myra

AU - Malay, Sunitha

AU - Shauver, Melissa J.

AU - Haase, Steven C.

AU - Lawton, Jeffrey N.

AU - Lien, John R.

AU - Momoh, Adeyiza O.

AU - Ozer, Kagan

AU - Sears, Erika D.

AU - Waljee, Jennifer F.

AU - Brown, Matthew S.

AU - Cho, Hoyune E.

AU - Michelotti, Brett F.

AU - Rozental, Tamara D.

AU - Appleton, Paul T.

AU - Rodriguez, Edward K.

AU - Deschamps, Laura N.

AU - Mattfolk, Lindsay

AU - Wagner, Katiri

AU - Blazar, Philip

AU - Earp, Brandon E.

AU - Floyd, W. Emerson

AU - Louie, Dexter L.

AU - Leversedge, Fraser J.

AU - Richard, Marc J.

AU - Ruch, David S.

AU - Finley, Suzanne

AU - Howe, Cameron

AU - Manson, Maria

AU - Whitfield, Janna

AU - Perey, Bertrand H.

AU - Apostle, Kelly

AU - Boyer, Dory

AU - Moola, Farhad

AU - Stone, Trevor

AU - Viskontas, Darius

AU - Zomar, Mauri

AU - Moon, Karyn

AU - Moon, Raely

AU - Kalliainen, Loree K.

AU - Ward, Christina M.

AU - Fletcher, James W.

AU - Heinrich, Cherrie A.

AU - Pico, Katharine S.

AU - Mahajan, Ashish Y.

AU - Hill, Brian W.

AU - Vang, Sandy

AU - Laporte, Dawn M.

AU - Hasenboehler, Erik A.

N1 - Funding Information: Research reported in this publication was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases and the National Institute on Aging of the National Institutes of Health under Award Number R01 AR062066 and by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award Number 2 K24-AR053120-06. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The WRIST Group consists of the following: Michigan Medicine (Coordinating Center): Kevin C. Chung, MD, MS (Principal Investigator); H. Myra Kim, ScD (Study Biostatistician); Steven C. Haase, MD; Jeffrey N. Lawton, MD; John R. Lien, MD; Adeyiza O. Momoh, MD; Kagan Ozer, MD; Erika D. Sears, MD, MS; Jennifer F. Waljee, MD, MPH; Matthew S. Brown, MD; Hoyune E. Cho, MD; Brett F. Michelotti, MD; Sunitha Malay, MPH (Study Coordinator); Melissa J. Shauver, MPH (Study Coordinator). Beth Israel Deaconess Medical Center: Tamara D. Rozental, MD (Co-Investigator); Paul T. Appleton, MD; Edward K. Rodriguez, MD, PhD; Laura N. Deschamps, DO; Lindsay Mattfolk, BA; Katiri Wagner. Brigham and Women's Hospital: Philip Blazar, MD (Co-Investigator); Brandon E. Earp, MD; W. Emerson Floyd; Dexter L. Louie, BS. Duke Health: Fraser J. Leversedge, MD (Co-Investigator); Marc J. Richard, MD; David, S. Ruch, MD; Suzanne Finley, CRC; Cameron Howe, CRC; Maria Manson; Janna Whitfield, BS. Fraser Health Authority: Bertrand H. Perey, MD (Co-Investigator); Kelly Apostle, MD, FRCSC; Dory Boyer, MD, FRCSC; Farhad Moola, MD, FRCSC; Trevor Stone, MD, FRCSC; Darius Viskontas, MD, FRCSC; Mauri Zomar, CCRP; Karyn Moon; Raely Moon. Health Partners Institute for Education and Research: Loree K. Kalliainen, MD, MA (Co-Investigator, now at University of North Carolina Health Care); Christina M. Ward, MD (Co-Investigator); James W. Fletcher, MD; Cherrie A. Heinrich, MD; Katharine S. Pico, MD; Ashish Y. Mahajan, MD; Brian W. Hill, MD; Sandy Vang, BA. Johns Hopkins Medicine: Dawn M. Laporte, MD (Co-Investigator); Erik A. Hasenboehler, MD; Scott D. Lifchez, MD; Greg M. Osgood, MD; Babar Shafiq, MD, MS; Jaimie T. Shores, MD; Vaishali Laljani. Kettering Health Network: H. Brent Bamberger, DO (Co-Investigator); Timothy W. Harman, DO; David W. Martineau, MD; Carla Robinson, PA-C, MPAS; Brandi Palmer, MS, PC, CCRP. London Health Sciences Centre: Ruby Grewal, MD, MS (Co-Investigator); Ken A. Faber, MD; Joy C. MacDermid, PhD (Study Epidemiologist); Kate Kelly, MSc, MPH; Katrina Munro; Joshua I. Vincent, PT, PhD. Massachusetts General Hospital: David Ring, MD, PhD (Co-Investigator, now at University of Texas Health Austin); Jesse B. Jupiter, MD, MA; Abigail Finger, BA; Jillian S. Gruber, MD; Rajesh K. Reddy; Taylor M. Pong; Emily R. Thornton, BSc. Mayo Clinic: David G. Dennison, MD (Co-Investigator); Sanjeev Kakar, MD; Marco Rizzo, MD; Alexander Y. Shin, MD; Tyson L. Scrabeck, CCRP. The MetroHealth System: Kyle Chepla, MD (Co-Investigator); Kevin Malone, MD; Harry A. Hoyen, MD; Blaine Todd Bafus, MD; Roderick B. Jordan, MD; Bram Kaufman, MD; Ali Totonchil, MD; Dana R. Hromyak, BS, RRT; Lisa Humbert, RN. National University of Singapore: Sandeep Sebastin, MCh (Co-Investigator), Sally Tay. Northwell Health: Kate W. Nellans, MD, MPH (Co-Investigator); Sara L. Merwin, MPH. Norton Healthcare: Ethan W. Blackburn, MD (Co-Investigator); Sandra J. Hanlin, APRN, NP-C; Barbara Patterson, BSN, CCRC. OrthoCarolina Research Institute: R. Glenn Gaston, MD (Co-Investigator); R. Christopher Cadderdon, MD; Erika Gordon Gantt, MD; John S. Gaul, MD; Daniel R. Lewis, MD; Bryan J. Loeffler, MD; Lois K. Osier, MD; Paul C. Perlik, MD; W. Alan Ward, MD; Benjamin Connell, BA, CCRC; Pricilla Haug, BA, CCRC; Caleb Michalek, BS, CCRC. Pan Am Clinic/University of Manitoba: Tod A. Clark, MD, MSc, FRCSC(Co-Investigator); Sheila McRae, MSc, PhD. University of Connecticut Health: Jennifer Moriatis Wolf, MD (Co-Investigator, now at University of Chicago Medicine); Craig M. Rodner, MD; Katy Coyle, RN. University of Oklahoma Medicine: Thomas P. Lehman, MD, PT (Co-Investigator); Yuri C. Lansinger, MD; Gavin D. O'Mahony, MD; Kathy Carl, BA, CCRP; Janet Wells. University of Pennsylvania Health System: David J. Bozentka, MD (Co-Investigator); L. Scott Levin, MD; David P. Steinberg, MD; Annamarie D. Horan, PhD; Denise Knox, BS; Kara Napolitano, BS. University of Pittsburgh Medical Center: John Fowler, MD (Co-Investigator); Robert Goitz, MD; Cathy A. Naccarelli; Joelle Tighe. University of Rochester: Warren C. Hammert, MD, DDS (Co-Investigator); Allison W. McIntyre, MPH; Krista L. Noble; Kaili Waldrick. University of Washington Medicine: Jeffery B. Friedrich, MD (Co-Investigator); David Bowman; Angela Wilson. Wake Forest Baptist Health: Zhongyu Li, MD, PhD (Co-Investigator); L. Andrew Koman, MD; Benjamin R. Graves, MD; Beth P. Smith, PhD; Debra Bullard. Funding Information: Research reported in this publication was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases and the National Institute on Aging of the National Institutes of Health under Award Number R01 AR062066 and by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award Number 2 K24-AR053120-06 . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: © 2019 American Society for Surgery of the Hand

PY - 2019/9

Y1 - 2019/9

N2 - Purpose: Current evidence on predictors of outcomes after distal radius fracture is often based on retrospective analyses or may be confounded by fracture type. Using data from the Wrist and Radius Injury Surgical Trial (WRIST), a 24-site randomized study of distal radius fracture treatment, in which all fractures are severe enough to warrant surgery, we set out to perform a secondary data analysis to explore predictors of better or worse hand outcomes. Methods: The primary outcome measure was the Michigan Hand Outcomes Questionnaire (MHQ) summary score 12 months after treatment. We used a regression tree analysis with recursive partitioning to identify subgroups of participants who experienced similar outcomes (ie, MHQ score) and to determine which baseline or treatment factors they had in common. Results: Factors most predictive of 12-month MHQ score were pain at enrollment, education, age, and number of comorbidities. Specifically, participants who had a high school education or less and also reported severe pain had the lowest MHQ scores. Conversely, participants with less pain and more education and who were age 87 years or younger with one or no comorbid condition had the highest MHQ scores. Treatment type or radiographic measurements assessed on post-reduction films did not affect 12-month outcomes. Conclusions: These results identified patient characteristics that can be used by surgeons to identify subgroups of patients who may experience similar hand outcomes. Type of study/level of evidence: Prognostic III.

AB - Purpose: Current evidence on predictors of outcomes after distal radius fracture is often based on retrospective analyses or may be confounded by fracture type. Using data from the Wrist and Radius Injury Surgical Trial (WRIST), a 24-site randomized study of distal radius fracture treatment, in which all fractures are severe enough to warrant surgery, we set out to perform a secondary data analysis to explore predictors of better or worse hand outcomes. Methods: The primary outcome measure was the Michigan Hand Outcomes Questionnaire (MHQ) summary score 12 months after treatment. We used a regression tree analysis with recursive partitioning to identify subgroups of participants who experienced similar outcomes (ie, MHQ score) and to determine which baseline or treatment factors they had in common. Results: Factors most predictive of 12-month MHQ score were pain at enrollment, education, age, and number of comorbidities. Specifically, participants who had a high school education or less and also reported severe pain had the lowest MHQ scores. Conversely, participants with less pain and more education and who were age 87 years or younger with one or no comorbid condition had the highest MHQ scores. Treatment type or radiographic measurements assessed on post-reduction films did not affect 12-month outcomes. Conclusions: These results identified patient characteristics that can be used by surgeons to identify subgroups of patients who may experience similar hand outcomes. Type of study/level of evidence: Prognostic III.

KW - Distal radius fracture

KW - older adults

KW - predictors of outcomes

UR - http://www.scopus.com/inward/record.url?scp=85069725471&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85069725471&partnerID=8YFLogxK

U2 - 10.1016/j.jhsa.2019.05.016

DO - 10.1016/j.jhsa.2019.05.016

M3 - Article

C2 - 31345563

AN - SCOPUS:85069725471

SN - 0363-5023

VL - 44

SP - 762

EP - 771

JO - Journal of Hand Surgery

JF - Journal of Hand Surgery

IS - 9

ER -

Predicting Outcomes After Distal Radius Fracture: A 24-Center International Clinical Trial of Older Adults

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