Predictors of improved survival for patients with retroperitoneal sarcoma

Katherine Giuliano, Neeraja Nagarajan, Joseph K. Canner, Christopher L. Wolfgang, Trinity Bivalacqua, Stephanie Terezakis, Joseph Herman, Eric B. Schneider, Nita Ahuja

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Background Retroperitoneal sarcomas are rare tumors that can be locally aggressive with high rates of recurrence. Given that data on survival in patients with retroperitoneal sarcomas are conflicting, we sought to use a nationwide cancer database to identify factors associated with survival in patients with retroperitoneal sarcomas. Methods The Surveillance, Epidemiology, and End Results database was utilized to identify patients with retroperitoneal sarcomas from 2002 to 2012. Univariable and multivariable survival analysis was performed using a generalized gamma parametric survival function. Results A total of 2,920 patients were included; overall 5- and 10-year survivals were 58.4% and 45.3%, respectively. On multivariable survival analysis, age, histologic type, grade, size, local extension, lymph node, and distant metastasis were associated with decreased survival (all P < .05). Patients undergoing operative resection survived 2.5 times longer (95% confidence interval: 2.0–3.0, P < .001) and those receiving radiation therapy 1.3 times longer (95% confidence interval: 1.1–1.6, P = .001), respectively. Conclusion During the past decade, retroperitoneal sarcoma patients treated with radiation demonstrate longer survival compared with patients who did not receive radiation. Further study is needed to fully elucidate the mechanisms that underlie the radiation-related survival benefit observed in this study.

Original languageEnglish (US)
Pages (from-to)1628-1635
Number of pages8
JournalSurgery (United States)
Volume160
Issue number6
DOIs
StatePublished - Dec 1 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Inc.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

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