Abstract
Cocaine-induced paranoia (CIP) has recently shown a relationship to genetic factors that may moderate disulfiram treatment response in cocaine-dependent individuals. However, little research has examined CIP under controlled laboratory conditions. This study examined subjective and physiological responses to a 0.4 mg/kg dose of smoked cocaine in a human laboratory setting with 23 male and 21 female cocaine users. Twenty-nine of 44 participants (67%) reported feeling Paranoid/Suspicious in response to cocaine. Those who reported feeling Paranoid/Suspicious were more likely to be older and male. Further studies are warranted to investigate the mechanisms of gender influence on CIP, and CIP in pharmacotherapy development for cocaine-dependent individuals.
Original language | English (US) |
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Pages (from-to) | 1245-1251 |
Number of pages | 7 |
Journal | Addictive Behaviors |
Volume | 31 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2006 |
Bibliographical note
Funding Information:This research was supported by grants from National Institute on Drug Abuse (P-50 DA09259) and from the National Center for Research Resources (MO1-RR00400).
Keywords
- Cocaine-induced paranoia
- Crack-cocaine
- Gender differences