Preliminary report: No association between TCF7L2 rs7903146 and euglycemic-clamp-derived insulin sensitivity in a mixed-age cohort

Laura J. Rasmussen-Torvik; James S. Pankow; David R. Jacobs; Alan R. Sinaiko

doi:10.1016/j.metabol.2009.04.023

Preliminary report: No association between TCF7L2 rs7903146 and euglycemic-clamp-derived insulin sensitivity in a mixed-age cohort

Laura J. Rasmussen-Torvik, James S. Pankow, David R. Jacobs, Alan R. Sinaiko

Epidemiology

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Abstract

There are conflicting reports about the significance of TCF7L2 single nucleotide polymorphism rs7903146, a single nucleotide polymorphism found to be associated with type 2 diabetes mellitus in several genomewide association studies, and insulin sensitivity. The association of rs7903146 and euglycemic-clamp-derived insulin sensitivity was tested in a cohort of children and their parents. Four hundred seventy whites (from 226 families) and 89 African Americans (from 48 families) were included in the analysis. No significant associations were seen between rs7903146 and insulin sensitivity. Adjusted genotype means were consistent across races and generational subgroups.

Original language	English (US)
Pages (from-to)	1369-1371
Number of pages	3
Journal	Metabolism: clinical and experimental
Volume	58
Issue number	10
DOIs	https://doi.org/10.1016/j.metabol.2009.04.023
State	Published - Oct 2009

Bibliographical note

Funding Information:
This study was supported by grants HL52851 and M01RR00400 from the National Institutes of Health. LJR-T is supported by the National Heart, Lung, and Blood Institute training grant T32 HL07779.

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abstract = "There are conflicting reports about the significance of TCF7L2 single nucleotide polymorphism rs7903146, a single nucleotide polymorphism found to be associated with type 2 diabetes mellitus in several genomewide association studies, and insulin sensitivity. The association of rs7903146 and euglycemic-clamp-derived insulin sensitivity was tested in a cohort of children and their parents. Four hundred seventy whites (from 226 families) and 89 African Americans (from 48 families) were included in the analysis. No significant associations were seen between rs7903146 and insulin sensitivity. Adjusted genotype means were consistent across races and generational subgroups.",

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AU - Sinaiko, Alan R.

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Preliminary report: No association between TCF7L2 rs7903146 and euglycemic-clamp-derived insulin sensitivity in a mixed-age cohort

Abstract

Bibliographical note

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