Preliminary results of a prospective randomized trial for treatment of severely brain-injured patients with hyperbaric oxygen

There is considerable evidence that hyperbaric oxygen (HBO) reduces intracranial pressure by causing cerebral vasoconstriction and decreased cerebral blood flow, while simultaneously supplying optimal amounts of oxygen for efficient cerebral aerobic glucose metabolism. The preliminary results of a prospective randomized clinical trial in a carefully defined group of patients with severe brain injuries treated with HBO are suggestive of a beneficial response. The rationale, protocol, and preliminary results of this ongoing study are presented.