Abstract
Screening studies for microbial transformation products of stemodin [2] have identified a number of microbial metabolites. Scale-up fermentation with Rhizopus arrhizus ATCC 11145 and Streptomyces sp. NRRL 5691 have resulted in the production of five metabolites that have been characterized with the use of 2D nmr and X-ray techniques. These metabolites have been identified as 18-hydroxystemodin [6], 16,18-dihydroxystemodin [7], 8β-hydroxystemodin [8], 8β, 18-dihydroxystemodin [9], and 7β,8β-dihydroxystemodin [10]. The antiviral activity and cytotoxicity of the isolated metabolites have been evaluated.
Original language | English (US) |
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Pages (from-to) | 1543-1552 |
Number of pages | 10 |
Journal | Journal of Natural Products |
Volume | 54 |
Issue number | 6 |
DOIs | |
State | Published - Nov 1 1991 |