Preparation, Characterization, and antiviral activity of microbial metabolites of stemodin

Charles D. Hufford, Farid A. Badria, Mohamed Abou-Karam, W. Thomas Shier, Robin D. Rogers

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Screening studies for microbial transformation products of stemodin [2] have identified a number of microbial metabolites. Scale-up fermentation with Rhizopus arrhizus ATCC 11145 and Streptomyces sp. NRRL 5691 have resulted in the production of five metabolites that have been characterized with the use of 2D nmr and X-ray techniques. These metabolites have been identified as 18-hydroxystemodin [6], 16,18-dihydroxystemodin [7], 8β-hydroxystemodin [8], 8β, 18-dihydroxystemodin [9], and 7β,8β-dihydroxystemodin [10]. The antiviral activity and cytotoxicity of the isolated metabolites have been evaluated.

Original languageEnglish (US)
Pages (from-to)1543-1552
Number of pages10
JournalJournal of Natural Products
Volume54
Issue number6
DOIs
StatePublished - Nov 1 1991

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