Abstract
A novel route for the conversion of anilides into 3-alkyl-oxindoles is described in which a copper(II)-mediated cyclization process is followed by an acid-mediated decarboxyalkylation. Scope and limitation studies are reported together with a telescoped variant which incorporates in situ N-deprotection.
Original language | English (US) |
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Pages (from-to) | 934-938 |
Number of pages | 5 |
Journal | Synlett |
Issue number | 6 |
DOIs | |
State | Published - 2010 |
Externally published | Yes |
Keywords
- 3-alkyl-oxindoles
- Anilides
- C-H activation
- Copper(II) catalysis
- Cyclisation
- Decarboxyalkylation
- Oxindoles