Prevalence and prognosis of electrocardiographic left ventricular hypertrophy, ST segment depression and negative T-wave: The Copenhagen City Heart Study

C. T. Larsen, J. Dahlin, H. Blackburn, H. Scharling, M. Appleyard, B. Sigurd, P. Schnohr

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102 Scopus citations

Abstract

Aims: To evaluate the prevalence and the independent prognosis of electrocardiographic left ventricular hypertrophy by voltage only, ST depression and negative T wave, isolated negative T wave and left ventricular hypertrophy plus ST depression and negative T wave for cardiac morbidity and mortality, without known ischaemic heart disease at baseline. Methods and Results: Follow-up data from the Copenhagen City Heart Study were used. Subjects were 5243 men and 6391 women, age range 25-74 years. Endpoints were (1) myocardial infarction, (2) ischaemic heart disease and (3) cardiovascular disease mortality. Relative risk was age- and sex-adjusted, and multivariately adjusted for known cardiovascular risk factors. During 7 years follow-up, left ventricular hypertrophy plus ST depression and negative T wave had an age-adjusted relative risk of 3.78 (95% confidence interval 2.29-6.25) for myocardial infarction, 4.27 (2.95-6.16) for ischaemic heart disease and 3.75 (2.41-5.85) for cardiovascular disease. A negative T wave, ST depression and negative T wave changes, and left ventricular hypertrophy with negative T wave also carry independent prognostic information for myocardial infarction, ischaemic heart disease and cardiovascular disease. Conclusions Electrocardiographic left ventricular hypertrophy with ST depression and negative T wave changes are the electrocardiographic abnormalities with the greatest prognostic information for future cardiac events. Electrocardiographic negative T waves, ST depression and negative T wave abnormalities and left ventricular hypertrophy with negative T waves, also have prognostic information.

Original languageEnglish (US)
Pages (from-to)315-324
Number of pages10
JournalEuropean heart journal
Volume23
Issue number4
DOIs
StatePublished - Feb 2002

Bibliographical note

Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.

Keywords

  • Electrocardiographic
  • Epidemiology
  • Left ventricular hypertrophy
  • Prognosis
  • Risk factors

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