Prevention of Bone Growth Defects, Increased Bone Resorption and Marrow Adiposity with Folinic Acid in Rats Receiving Long-Term Methotrexate

Agriculture & Biology

• bone resorption 100%
• adiposity 94%
• methotrexate 93%
• bone marrow 77%
• osteoclasts 66%
• bones 61%
• growth plate 46%
• interleukin-1 42%
• acids 40%
• rats 37%
• pediatrics 30%
• chondrocytes 27%
• drug therapy 23%
• preserves 22%
• apoptosis 22%
• antidotes 16%
• bone marrow cells 14%
• pathophysiology 14%
• osteoblasts 14%
• neutralizing antibodies 13%
• long term effects 11%
• protective effect 11%
• neoplasms 9%
• dosage 6%

Medicine & Life Sciences

• Leucovorin 86%
• Bone Development 80%
• Adiposity 75%
• Bone Resorption 73%
• Methotrexate 69%
• Bone Marrow 52%
• Osteoclasts 49%
• Growth Plate 43%
• Interleukin-1 36%
• Chondrocytes 24%
• Pediatrics 15%
• Antidotes 15%
• Apoptosis 14%
• Drug Therapy 14%
• Neutralizing Antibodies 12%
• Osteoblasts 11%
• Bone Marrow Cells 11%
• Survivors 10%
• Bone and Bones 7%
• Growth 6%
• Therapeutics 5%
• In Vitro Techniques 5%
• Neoplasms 3%

Chemical Compounds

• Methotrexate 90%
• Plate Like Crystal 33%
• Plasma 26%
• Acid 25%
• Antidote 20%
• Protective 11%
• Dose 11%
• Volume 8%