Probes for imidazoline binding sites: Synthesis and evaluation of a selective, irreversible I2 ligand

Philippa A. Coates; Peter Grundt; Emma S.J. Robinson; David J. Nutt; Robin Tyacke; Alan L. Hudson; John W. Lewis; Stephen M. Husbands

doi:10.1016/S0960-894X(00)00062-7

Probes for imidazoline binding sites: Synthesis and evaluation of a selective, irreversible I₂ ligand

Philippa A. Coates, Peter Grundt, Emma S.J. Robinson, David J. Nutt, Robin Tyacke, Alan L. Hudson, John W. Lewis, Stephen M. Husbands

Chemistry & Biochemistry

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

An irreversible ligand (7) has been prepared based on the selective I₂ ligand 2-BFI. Compound 7 displayed high affinity and selectivity for I₂-sites and has been shown to irreversibly bind to these sites in rat brain. Compound 7 should, therefore, prove an invaluable tool for the further elucidation of I₂-site function. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original language	English (US)
Pages (from-to)	605-607
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	10
Issue number	6
DOIs	https://doi.org/10.1016/S0960-894X(00)00062-7
State	Published - Mar 20 2000

Access

10.1016/S0960-894X(00)00062-7

OpenUrl availability

Full text

Cite this

@article{eb3df52f31cb457883b662bfa31d6f66,

title = "Probes for imidazoline binding sites: Synthesis and evaluation of a selective, irreversible I2 ligand",

abstract = "An irreversible ligand (7) has been prepared based on the selective I2 ligand 2-BFI. Compound 7 displayed high affinity and selectivity for I2-sites and has been shown to irreversibly bind to these sites in rat brain. Compound 7 should, therefore, prove an invaluable tool for the further elucidation of I2-site function. (C) 2000 Elsevier Science Ltd. All rights reserved.",

author = "Coates, {Philippa A.} and Peter Grundt and Robinson, {Emma S.J.} and Nutt, {David J.} and Robin Tyacke and Hudson, {Alan L.} and Lewis, {John W.} and Husbands, {Stephen M.}",

year = "2000",

month = mar,

day = "20",

doi = "10.1016/S0960-894X(00)00062-7",

language = "English (US)",

volume = "10",

pages = "605--607",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "6",

}

TY - JOUR

T1 - Probes for imidazoline binding sites

T2 - Synthesis and evaluation of a selective, irreversible I2 ligand

AU - Coates, Philippa A.

AU - Grundt, Peter

AU - Robinson, Emma S.J.

AU - Nutt, David J.

AU - Tyacke, Robin

AU - Hudson, Alan L.

AU - Lewis, John W.

AU - Husbands, Stephen M.

PY - 2000/3/20

Y1 - 2000/3/20

N2 - An irreversible ligand (7) has been prepared based on the selective I2 ligand 2-BFI. Compound 7 displayed high affinity and selectivity for I2-sites and has been shown to irreversibly bind to these sites in rat brain. Compound 7 should, therefore, prove an invaluable tool for the further elucidation of I2-site function. (C) 2000 Elsevier Science Ltd. All rights reserved.

AB - An irreversible ligand (7) has been prepared based on the selective I2 ligand 2-BFI. Compound 7 displayed high affinity and selectivity for I2-sites and has been shown to irreversibly bind to these sites in rat brain. Compound 7 should, therefore, prove an invaluable tool for the further elucidation of I2-site function. (C) 2000 Elsevier Science Ltd. All rights reserved.

UR - http://www.scopus.com/inward/record.url?scp=0034689585&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034689585&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(00)00062-7

DO - 10.1016/S0960-894X(00)00062-7

M3 - Article

C2 - 10741563

AN - SCOPUS:0034689585

SN - 0960-894X

VL - 10

SP - 605

EP - 607

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 6

ER -

Probes for imidazoline binding sites: Synthesis and evaluation of a selective, irreversible I₂ ligand

Abstract

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this