Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques

Nichole R Klatt; Lauren A Canary; Xiaoyong Sun; Carol L Vinton; Nicholas T Funderburg; David R Morcock; Mariam Quiñones; Clayton B Deming; Molly Perkins; Daria J Hazuda; Michael D Miller; Michael M Lederman; Julie A Segre; Jeffrey D Lifson; Elias K Haddad; Jacob D Estes; Jason M Brenchley

doi:10.1172/JCI66227

Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques

Nichole R Klatt, Lauren A Canary, Xiaoyong Sun, Carol L Vinton, Nicholas T Funderburg, David R Morcock, Mariam Quiñones, Clayton B Deming, Molly Perkins, Daria J Hazuda, Michael D Miller, Michael M Lederman, Julie A Segre, Jeffrey D Lifson, Elias K Haddad, Jacob D Estes, Jason M Brenchley

Research output: Contribution to journal › Article › peer-review

134 Scopus citations

Abstract

HIV infection results in gastrointestinal (GI) tract damage, microbial translocation, and immune activation, which are not completely ameliorated with suppression of viremia by antiretroviral (ARV) therapy. Furthermore, increased morbidity and mortality of ARV-treated HIV-infected individuals is associated with these dysfunctions. Thus, to enhance GI tract physiology, we treated SIV-infected pigtail macaques with ARVs, probiotics, and prebiotics or with ARVs alone. This synbiotic treatment resulted in increased frequency and functionality of GI tract APCs, enhanced reconstitution and functionality of CD4+ T cells, and reduced fibrosis of lymphoid follicles in the colon. Thus, ARV synbiotic supplementation in HIV-infected individuals may improve GI tract immunity and thereby mitigate inflammatory sequelae, ultimately improving prognosis.

Original language	English (US)
Pages (from-to)	903-7
Number of pages	5
Journal	The Journal of clinical investigation
Volume	123
Issue number	2
DOIs	https://doi.org/10.1172/JCI66227
State	Published - Feb 2013
Externally published	Yes

Keywords

Adjuvants, Immunologic/administration & dosage
Animals
Anti-Retroviral Agents/administration & dosage
CD4-Positive T-Lymphocytes/immunology
Combined Modality Therapy
Dietary Supplements
Disease Models, Animal
Gastrointestinal Tract/immunology
HIV Infections/immunology
Humans
Macaca nemestrina
Prebiotics
Probiotics/administration & dosage
Simian Acquired Immunodeficiency Syndrome/genetics
Transcriptome

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1172/JCI66227

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Klatt, N. R., Canary, L. A., Sun, X., Vinton, C. L., Funderburg, N. T., Morcock, D. R., Quiñones, M., Deming, C. B., Perkins, M., Hazuda, D. J., Miller, M. D., Lederman, M. M., Segre, J. A., Lifson, J. D., Haddad, E. K., Estes, J. D., & Brenchley, J. M. (2013). Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques. The Journal of clinical investigation, 123(2), 903-7. https://doi.org/10.1172/JCI66227

Klatt, NR, Canary, LA, Sun, X, Vinton, CL, Funderburg, NT, Morcock, DR, Quiñones, M, Deming, CB, Perkins, M, Hazuda, DJ, Miller, MD, Lederman, MM, Segre, JA, Lifson, JD, Haddad, EK, Estes, JD & Brenchley, JM 2013, 'Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques', The Journal of clinical investigation, vol. 123, no. 2, pp. 903-7. https://doi.org/10.1172/JCI66227

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abstract = "HIV infection results in gastrointestinal (GI) tract damage, microbial translocation, and immune activation, which are not completely ameliorated with suppression of viremia by antiretroviral (ARV) therapy. Furthermore, increased morbidity and mortality of ARV-treated HIV-infected individuals is associated with these dysfunctions. Thus, to enhance GI tract physiology, we treated SIV-infected pigtail macaques with ARVs, probiotics, and prebiotics or with ARVs alone. This synbiotic treatment resulted in increased frequency and functionality of GI tract APCs, enhanced reconstitution and functionality of CD4+ T cells, and reduced fibrosis of lymphoid follicles in the colon. Thus, ARV synbiotic supplementation in HIV-infected individuals may improve GI tract immunity and thereby mitigate inflammatory sequelae, ultimately improving prognosis.",

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AU - Funderburg, Nicholas T

AU - Morcock, David R

AU - Quiñones, Mariam

AU - Deming, Clayton B

AU - Perkins, Molly

AU - Hazuda, Daria J

AU - Miller, Michael D

AU - Lederman, Michael M

AU - Segre, Julie A

AU - Lifson, Jeffrey D

AU - Haddad, Elias K

AU - Estes, Jacob D

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AB - HIV infection results in gastrointestinal (GI) tract damage, microbial translocation, and immune activation, which are not completely ameliorated with suppression of viremia by antiretroviral (ARV) therapy. Furthermore, increased morbidity and mortality of ARV-treated HIV-infected individuals is associated with these dysfunctions. Thus, to enhance GI tract physiology, we treated SIV-infected pigtail macaques with ARVs, probiotics, and prebiotics or with ARVs alone. This synbiotic treatment resulted in increased frequency and functionality of GI tract APCs, enhanced reconstitution and functionality of CD4+ T cells, and reduced fibrosis of lymphoid follicles in the colon. Thus, ARV synbiotic supplementation in HIV-infected individuals may improve GI tract immunity and thereby mitigate inflammatory sequelae, ultimately improving prognosis.

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KW - Prebiotics

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Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques

Abstract

Keywords

PubMed: MeSH publication types

UN SDGs

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