TY - JOUR
T1 - Proctitis after conventional external radiation therapy for prostate cancer
T2 - Importance of minimizing posterior rectal dose
AU - Cho, Kwan H.
AU - Lee, Chung K.K.
AU - Levitt, Seymour H.
PY - 1995/6
Y1 - 1995/6
N2 - PURPOSE: To identify factors associated with the prevalence of radiation proctitis in patients with prostate cancer treated with external radiation therapy and to determine if a dose-response relationship exists. MATERIALS AND METHODS: The study included 101 prostate cancer patients treated at the University of Minnesota Hospital and Clinics between 1970 and 1987. Radiation therapy at a daily dose of 175-200 cGy was given for 5 consecutive days per week for 7 weeks with a 10-24-MV linear accelerator. Mean dose to the prostate was 6,795 cGy (range, 5,579-7,417 cGy). Simulation radiographs obtained with rectal barium were analyzed in 51 patients. Doses were calculated at specific points in the boost field. RESULTS: Radiation proctitis developed in 19 patients. No pretreatment or treatment factors were associated with a higher prevalence of proctitis. Statistically significant correlation (P < .042) was found between the development of proctitis and dose to the posterior rectum. At χ2 analysis, proctitis was statistically significantly (P < .005) associated with posterior rectal doses of >5,000 cGy. CONCLUSION: A high posterior rectal dose (>5,000 cGy) is associated with increased prevalence of proctitis after radiation therapy.
AB - PURPOSE: To identify factors associated with the prevalence of radiation proctitis in patients with prostate cancer treated with external radiation therapy and to determine if a dose-response relationship exists. MATERIALS AND METHODS: The study included 101 prostate cancer patients treated at the University of Minnesota Hospital and Clinics between 1970 and 1987. Radiation therapy at a daily dose of 175-200 cGy was given for 5 consecutive days per week for 7 weeks with a 10-24-MV linear accelerator. Mean dose to the prostate was 6,795 cGy (range, 5,579-7,417 cGy). Simulation radiographs obtained with rectal barium were analyzed in 51 patients. Doses were calculated at specific points in the boost field. RESULTS: Radiation proctitis developed in 19 patients. No pretreatment or treatment factors were associated with a higher prevalence of proctitis. Statistically significant correlation (P < .042) was found between the development of proctitis and dose to the posterior rectum. At χ2 analysis, proctitis was statistically significantly (P < .005) associated with posterior rectal doses of >5,000 cGy. CONCLUSION: A high posterior rectal dose (>5,000 cGy) is associated with increased prevalence of proctitis after radiation therapy.
KW - Prostate, neoplasms
KW - Prostate, therapeutic radiology
KW - Rectum, therapeutic radiology
KW - Therapeutic radiology
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U2 - 10.1148/radiology.195.3.7753997
DO - 10.1148/radiology.195.3.7753997
M3 - Article
C2 - 7753997
AN - SCOPUS:0029026441
SN - 0033-8419
VL - 195
SP - 699
EP - 703
JO - Radiology
JF - Radiology
IS - 3
ER -