TY - JOUR
T1 - Production and dosimetry of [14O]water for PET activation studies
AU - Sajjad, Munawwar
AU - Zaini, Mehran R.
AU - Liow, Jeih San
AU - Rottenberg, David A.
AU - Strother, Stephen C.
N1 - Funding Information:
This work was partly supported by the National Institutes of Health grants MH57180 and NS33721.
PY - 2002/11/1
Y1 - 2002/11/1
N2 - [14O]water was produced by the 14N(p,n)14O reaction in quantities greater than 80mCi (EOB). The carbon-11 impurity in the final product was approximately 0.003±0.002% of 14O activity at EOB. A factor of 0.5±0.02 was obtained to correct the dose calibrator for the additional 2.313MeV γ-ray. The effective dose equivalent was calculated for 14O and 15O using MIRDOSE, and the 14O dose was found to be ≈70% of that for 15O. For scanner performance based on noise equivalent count measurements, the peak activity concentration for 14O was 30% lower than that for 15O. At their peak activity concentrations the noise equivalent count rate for 14O was found to be about 13% less than that for 15O.
AB - [14O]water was produced by the 14N(p,n)14O reaction in quantities greater than 80mCi (EOB). The carbon-11 impurity in the final product was approximately 0.003±0.002% of 14O activity at EOB. A factor of 0.5±0.02 was obtained to correct the dose calibrator for the additional 2.313MeV γ-ray. The effective dose equivalent was calculated for 14O and 15O using MIRDOSE, and the 14O dose was found to be ≈70% of that for 15O. For scanner performance based on noise equivalent count measurements, the peak activity concentration for 14O was 30% lower than that for 15O. At their peak activity concentrations the noise equivalent count rate for 14O was found to be about 13% less than that for 15O.
KW - O
KW - PET
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U2 - 10.1016/S0969-8043(02)00175-6
DO - 10.1016/S0969-8043(02)00175-6
M3 - Article
C2 - 12433034
AN - SCOPUS:0036826923
SN - 0969-8043
VL - 57
SP - 607
EP - 615
JO - Applied Radiation and Isotopes
JF - Applied Radiation and Isotopes
IS - 5
ER -