Profound tabletability deterioration of microcrystalline cellulose by magnesium stearate

Jiangnan Dun, Hongbo Chen, Changquan Calvin Sun

Research output: Contribution to journalArticlepeer-review

Abstract

Magnesium stearate (MgSt) is a common lubricant used in tablet formulations to facilitate tablet manufacturing by reducing ejection force. The use of MgSt in tablet formulation is known to potentially deteriorate tabletability of plastic powders and slow down drug dissolution. Here, we report surprisingly profound deterioration in tabletability of microcrystalline cellulose by hand-mixing. We also show that the hand mixing process is highly variable. To ensure the reproducibility of tabletability assessment of powders, hand-mixing should be used with caution. For research that employs hand mixing, mixing procedure should be carefully controlled and reported.

Original languageEnglish (US)
Article number119927
JournalInternational journal of pharmaceutics
Volume590
DOIs
StatePublished - Nov 30 2020

Bibliographical note

Publisher Copyright:
© 2020 Elsevier B.V.

Keywords

  • Lubrication
  • Magnesium stearate
  • Microcrystalline cellulose
  • Mixing intensity
  • Tabletability

PubMed: MeSH publication types

  • Journal Article

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