Abstract
Polycomb and trithorax group proteins are evolutionarily conserved chromatin components that maintain stable states of gene expression. Recent studies have identified and characterized several multiprotein complexes containing these transcriptional regulators. Advances in understanding molecular activities of these complexes in vitro, and functional domains present in their subunits, suggest that they control transcription through multistep mechanisms that involve nucleosome modification, chromatin remodeling, and interaction with general transcription factors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 210-218 |
| Number of pages | 9 |
| Journal | Current Opinion in Genetics and Development |
| Volume | 12 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 1 2002 |
Bibliographical note
Funding Information:We thank Ann Rougvie, Mike O'Connor and members of our laboratories for discussions and critical comments on the manuscript. We apologize to colleagues whose work we were unable to cite due to space limitations. Work in our laboratories is supported by grants from the National Institutes of Health.
