Movement of cells and tissues is a basic biological process that is used in development, wound repair, the immune response to bacterial invasion, tumour formation and metastasis, and the search for food and mates. While some cell movement is random, directed movement stimulated by extracellular signals is our focus here. This involves a sequence of steps in which cells first detect extracellular chemical and/or mechanical signals via membrane receptors that activate signal transduction cascades and produce intracellular signals. These intracellular signals control the motile machinery of the cell and thereby determine the spatial localization of the sites of force generation needed to produce directed motion. Understanding how force generation within cells and mechanical interactions with their surroundings, including other cells, are controlled in space and time to produce cell-level movement is a major challenge, and involves many issues that are amenable to mathematical modelling.
Bibliographical noteFunding Information:
T.B. is supported by BBSRC grant no. BB/M01150X/1. H.G.O. is supported by NSF grant DMS nos. 9517884 and 131974, and by the Simons Foundation. C.J.W. is supported by BBSRC grant no. BB/ L00271X/1. All thank the Isaac Newton Institute for Mathematical Sciences for its support during the programme ?Coupling geometric partial differential equations with physics for cell morphology, motility and pattern formation? supported by EPSRC grant no. EP/K032208/1
- Actin dynamics
- Multicellular morphogenesis
- Signal transduction