Progression of changes in the sensorial elements of the cochlear and peripheral vestibular systems: The otitis media continuum

Rafael da Costa Monsanto; Patricia Schachern; Michael M. Paparella; Sebahattin Cureoglu; Norma de Oliveira Penido

doi:10.1016/j.heares.2017.05.003

Progression of changes in the sensorial elements of the cochlear and peripheral vestibular systems: The otitis media continuum

Rafael da Costa Monsanto, Patricia Schachern, Michael M. Paparella, Sebahattin Cureoglu, Norma de Oliveira Penido

Otolaryngology

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Our study aimed to evaluate pathologic changes in the cochlear (inner and outer hair cells and stria vascularis) and vestibular (vestibular hair cells, dark, and transitional cells) sensorial elements in temporal bones from donors who had otitis media. We studied 40 temporal bones from such donors, which were categorized in serous otitis media (SOM), serous-purulent otitis media (SPOM), mucoid/mucoid-purulent otitis media (MOM/MPOM), and chronic otitis media (COM); control group comprised 10 nondiseased temporal bones. We found significant loss of inner and outer cochlear hair cells in the basal turn of the SPOM, MOM/MPOM and COM groups; significant loss of vestibular hair cells was observed in the MOM/MPOM and COM groups. All otitis media groups had smaller mean area of the stria vascularis in the basal turn of the cochlea when compared to controls. In conclusion, our study demonstrated more severe pathologic changes in the later stages of the continuum of otitis media (MOM/MPOM and COM). Those changes seem to progress from the basal turn of the cochlea (stria vascularis, then inner and outer hair cells) to the middle turn of the cochlea and to the saccule and utricle in the MOM/MPOM and COM stages.

Original language	English (US)
Pages (from-to)	2-10
Number of pages	9
Journal	Hearing Research
Volume	351
DOIs	https://doi.org/10.1016/j.heares.2017.05.003
State	Published - Aug 2017

Bibliographical note

Funding Information:
The authors thank all study participants for their contributions; Mary E. Knatterud, PhD, for editing the manuscript; Grace Sinae Park, BS, and Nevra Keskin, for great technical support and help during the gathering of the data. We also thank our funding sources, including the National Institute on Deafness and Other Communication Disorders of the US National Institutes of Health, grant U24 DC011968; the International Hearing Foundation; the Starkey Hearing Foundation; and the Lions 5M Hearing Foundation.

Publisher Copyright:
© 2017 Elsevier B.V.

Keywords

Cochlear hair cells
Cochlear pathology
Otitis media
Stria vascularis
Vestibular hair cells
Vestibular pathology

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10.1016/j.heares.2017.05.003

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557455

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title = "Progression of changes in the sensorial elements of the cochlear and peripheral vestibular systems: The otitis media continuum",

abstract = "Our study aimed to evaluate pathologic changes in the cochlear (inner and outer hair cells and stria vascularis) and vestibular (vestibular hair cells, dark, and transitional cells) sensorial elements in temporal bones from donors who had otitis media. We studied 40 temporal bones from such donors, which were categorized in serous otitis media (SOM), serous-purulent otitis media (SPOM), mucoid/mucoid-purulent otitis media (MOM/MPOM), and chronic otitis media (COM); control group comprised 10 nondiseased temporal bones. We found significant loss of inner and outer cochlear hair cells in the basal turn of the SPOM, MOM/MPOM and COM groups; significant loss of vestibular hair cells was observed in the MOM/MPOM and COM groups. All otitis media groups had smaller mean area of the stria vascularis in the basal turn of the cochlea when compared to controls. In conclusion, our study demonstrated more severe pathologic changes in the later stages of the continuum of otitis media (MOM/MPOM and COM). Those changes seem to progress from the basal turn of the cochlea (stria vascularis, then inner and outer hair cells) to the middle turn of the cochlea and to the saccule and utricle in the MOM/MPOM and COM stages.",

keywords = "Cochlear hair cells, Cochlear pathology, Otitis media, Stria vascularis, Vestibular hair cells, Vestibular pathology",

author = "Monsanto, {Rafael da Costa} and Patricia Schachern and Paparella, {Michael M.} and Sebahattin Cureoglu and Penido, {Norma de Oliveira}",

note = "Funding Information: The authors thank all study participants for their contributions; Mary E. Knatterud, PhD, for editing the manuscript; Grace Sinae Park, BS, and Nevra Keskin, for great technical support and help during the gathering of the data. We also thank our funding sources, including the National Institute on Deafness and Other Communication Disorders of the US National Institutes of Health, grant U24 DC011968; the International Hearing Foundation; the Starkey Hearing Foundation; and the Lions 5M Hearing Foundation. Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

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AU - Schachern, Patricia

AU - Paparella, Michael M.

AU - Cureoglu, Sebahattin

AU - Penido, Norma de Oliveira

N1 - Funding Information: The authors thank all study participants for their contributions; Mary E. Knatterud, PhD, for editing the manuscript; Grace Sinae Park, BS, and Nevra Keskin, for great technical support and help during the gathering of the data. We also thank our funding sources, including the National Institute on Deafness and Other Communication Disorders of the US National Institutes of Health, grant U24 DC011968; the International Hearing Foundation; the Starkey Hearing Foundation; and the Lions 5M Hearing Foundation. Publisher Copyright: © 2017 Elsevier B.V.

PY - 2017/8

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N2 - Our study aimed to evaluate pathologic changes in the cochlear (inner and outer hair cells and stria vascularis) and vestibular (vestibular hair cells, dark, and transitional cells) sensorial elements in temporal bones from donors who had otitis media. We studied 40 temporal bones from such donors, which were categorized in serous otitis media (SOM), serous-purulent otitis media (SPOM), mucoid/mucoid-purulent otitis media (MOM/MPOM), and chronic otitis media (COM); control group comprised 10 nondiseased temporal bones. We found significant loss of inner and outer cochlear hair cells in the basal turn of the SPOM, MOM/MPOM and COM groups; significant loss of vestibular hair cells was observed in the MOM/MPOM and COM groups. All otitis media groups had smaller mean area of the stria vascularis in the basal turn of the cochlea when compared to controls. In conclusion, our study demonstrated more severe pathologic changes in the later stages of the continuum of otitis media (MOM/MPOM and COM). Those changes seem to progress from the basal turn of the cochlea (stria vascularis, then inner and outer hair cells) to the middle turn of the cochlea and to the saccule and utricle in the MOM/MPOM and COM stages.

AB - Our study aimed to evaluate pathologic changes in the cochlear (inner and outer hair cells and stria vascularis) and vestibular (vestibular hair cells, dark, and transitional cells) sensorial elements in temporal bones from donors who had otitis media. We studied 40 temporal bones from such donors, which were categorized in serous otitis media (SOM), serous-purulent otitis media (SPOM), mucoid/mucoid-purulent otitis media (MOM/MPOM), and chronic otitis media (COM); control group comprised 10 nondiseased temporal bones. We found significant loss of inner and outer cochlear hair cells in the basal turn of the SPOM, MOM/MPOM and COM groups; significant loss of vestibular hair cells was observed in the MOM/MPOM and COM groups. All otitis media groups had smaller mean area of the stria vascularis in the basal turn of the cochlea when compared to controls. In conclusion, our study demonstrated more severe pathologic changes in the later stages of the continuum of otitis media (MOM/MPOM and COM). Those changes seem to progress from the basal turn of the cochlea (stria vascularis, then inner and outer hair cells) to the middle turn of the cochlea and to the saccule and utricle in the MOM/MPOM and COM stages.

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KW - Stria vascularis

KW - Vestibular hair cells

KW - Vestibular pathology

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Progression of changes in the sensorial elements of the cochlear and peripheral vestibular systems: The otitis media continuum

Abstract

Bibliographical note

Keywords

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