Abstract
Objective: To evaluate the use of a high dose of nitroglycerin (NTG) for prophylaxis against myocardial ischemia and infarction in patients undergoing coronary artery bypass graft (CABG) surgery with accelerated recovery. Design: Prospective, double-blind, placebo-controlled randomized study. Setting: A university-based medical center. Participants: Forty adult patients presenting for elective CABG surgery. Interventions: Forty patients were divided into 2 blinded study groups. Twenty patients received 2 μg/kg/min of NTG starting before induction of anesthesia and continuing for 6 hours after extubation in the intensive care unit. The placebo group (n = 20) received normal saline during this same interval. Measurements and Main Results: Hemodynamics, incidence and severity of myocardial ischemia, and myocardial infarction rates were determined. There were no differences in hemodynamic parameters between groups. The incidence of ischemia was approximately 35% in each group. Myocardial infarction (as determined by elevated creatine kinase-MB fraction, troponin I, and electrocardiogram criteria) was 10% in the placebo group and 5% in the NTG group (p = 0.234). Conclusions: This study shows a high incidence of myocardial ischemia and infarction in patients presenting for CABG surgery with an accelerated recovery management scheme. NTG was well tolerated clinically; however, it was not found to be protective against myocardial ischemia or infarction in this setting. Copyright (C) 2000 by W.B. Saunders Company.
Original language | English (US) |
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Pages (from-to) | 571-575 |
Number of pages | 5 |
Journal | Journal of Cardiothoracic and Vascular Anesthesia |
Volume | 14 |
Issue number | 5 |
DOIs | |
State | Published - Jan 1 2000 |
Keywords
- Coronary artery bypass graft surgery
- Infarction
- Myocardial ischemia
- Nitroglycerin
- Pharmacology
- Surgery