Propofol-associated rhabdomyolysis with cardiac involvement in adults: Chemical and anatomic findings

Edward B. Stelow, Vandita P. Johari, Stephen A. Smith, John T. Crosson, Fred S. Apple

Research output: Contribution to journalArticlepeer-review

95 Scopus citations

Abstract

Propofol, a central-acting sedative agent, has been implicated in the development of rhabdomyolysis in children. We describe two adults who developed rhabdomyolysis after receiving high rates of propofol infusion. Rhabdomyolysis of both skeletal and cardiac muscle was suggested in both patients by marked increases of creatine kinase (>170 000 U/L) and cardiac troponin I (11 and 46 μg/L in patients one and two, respectively). Creatine kinase and cardiac troponin I values were highly correlated in each patent (r = 0.786 and 0.988 in patients one and two, respectively). Autopsy of one patient confirmed the diagnosis of skeletal and cardiac rhabdomyolysis. (C) 2000 American Association for Clinical Chemistry.

Original languageEnglish (US)
Pages (from-to)577-581
Number of pages5
JournalClinical chemistry
Volume46
Issue number4
DOIs
StatePublished - 2000

Fingerprint

Dive into the research topics of 'Propofol-associated rhabdomyolysis with cardiac involvement in adults: Chemical and anatomic findings'. Together they form a unique fingerprint.

Cite this