Prospective blinded trial comparing 45-mL and 90-mL doses of oral sodium phosphate for bowel preparation before computed tomographic colonography

David H. Kim, Perry J. Pickhardt, J. Louis Hinshaw, Andrew J. Taylor, Rajat Mukherjee, Patrick R. Pfau

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

OBJECTIVE: To compare the efficacy of computed tomographic colonography (CTC) bowel preparation using single- (45 mL) versus double-dose sodium phosphate. MATERIALS AND METHODS: A hundred consecutive patients undergoing screening CTC were randomly assigned with either single (45 mL) or double dose of sodium phosphate. Stool/fluid tagging remained constant. Two radiologists with extensive CTC experience, blinded to the groups, prospectively scored the colon for residual stool and fluid by using a 4-point scale. RESULTS: There was an excellent cleansing in both groups characterized by low stool/fluid scores. A stool score of 1 or 2 (indicating a stool-free segment or only minimal particles <5 mm) was seen in 90.3% (271/300) of segments in the single-dose group and 87% (261/300) in the double-dose group. Similarly, there was minimal residual fluid with a score of 1 or 2 (indicating <25% of lumen occupied by fluid) in 82% (488/600) of segments in the single-dose group and 87% (522/600) in the double-dose group. Overall, no significant associations were noted between the sodium phosphate regimens and residual stool/fluid in most colonic segments. In addition, no significant differences were seen in the stool or fluid tagging. CONCLUSIONS: Both single- and double-dose sodium phosphate resulted in excellent colonic cleansing without any significant differences. Tagging of residual stool and fluid was equally excellent for both groups. These findings indicate that a single 45-mL dose of oral sodium phosphate, in conjunction with stool and fluid tagging, results in high-quality CTC bowel preparation that is comparable to the clinically proven double-dose regimen.

Original languageEnglish (US)
Pages (from-to)53-58
Number of pages6
JournalJournal of Computer Assisted Tomography
Volume31
Issue number1
DOIs
StatePublished - Jan 1 2007

Keywords

  • Bowel preparation
  • CT colonography
  • Sodium phosphate

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