Prostaglandins as reducing agents: A model of adenylate cyclase activation?

D. A. Peterson, B. Kelly, N. Mehta, J. M. Gerrard

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

It has been suggested that adenylate cyclase activation involves reduction of a disulfide linkage. Prostaglandin E1 (PGE1), prostaglandin E2 (PGE2), prostaglandin I2 (PGI2) and prostaglandin F2α (PGF) were tested for their ability to act as reducing agents with either cytochrome c, or the disulfide 5,5′-dithiobis(2-nitrobenzoic acid) (DTNB), the latter with a catalytic amount of ferric chloride. PGE1, PGE2, and PGI2 significantly reduced cytochrome c while PGF did not. PGE1, PGE2 and PGI2 reduced DTNB while PGF did not. The results are consistent with the postulate that prostaglandins which are effective in activating adenylate cyclase can act as reducing agents and might be involved in reductive activation of adenylate cyclase.

Original languageEnglish (US)
Pages (from-to)667-671
Number of pages5
JournalProstaglandins
Volume36
Issue number5
DOIs
StatePublished - Nov 1988

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