Protective role of hypoxia-inducible factor-1α-dependent CD39 and CD73 in fulminant acute liver failure

Eunyoung Tak, Dong Hwan Jung, Seok Hwan Kim, Gil Chun Park, Dae Young Jun, Jooyoung Lee, Bo hyun Jung, Varvara A. Kirchner, Shin Hwang, Gi Won Song, Sung Gyu Lee

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Acute liver failure (ALF) is a severe life-threatening disease which usually arises in patients with-irreversible liver illnesses. Although human ectonucleotide triphosphate diphosphohydrolase-1, E-NTPDase1 (CD39) and ecto-5′-nucleotidase, Ecto5′NTase (CD73) are known to protect tissues from ALF, the expression and function of CD39 and CD73 during ALF are currently not fully investigated. We tested whether CD39 and CD73 are upregulated by hypoxia inducible factor (HIF)-1α, and improve ischemic tolerance to ALF. To test our hypothesis, liver biopsies were obtained and we found that CD39 and CD73 mRNA and proteins from human specimens were dramatically elevated in ALF. We investigated that induction of CD39 and CD73 in ALF-related with wild type mice. In contrast, deletion of cd39 and cd73 mice has severe ALF. In this study, we concluded that CD39 and CD73 are molecular targets for the development of drugs for ALF patients care.

Original languageEnglish (US)
Pages (from-to)72-81
Number of pages10
JournalToxicology and Applied Pharmacology
Volume314
DOIs
StatePublished - Jan 1 2017

Bibliographical note

Funding Information:
The present research work was partially supported by research funds from the Asan Institute for Life Sciences (Tak EY, 15-662 ), the National Research Foundation of Korea ( NRF-2015K1A4A3046807 ), Mitsubishi Tanabe Pharma Korea Co., Ltd. (Lee SG, 2015-1390 ) and Yuhan corporation (Lee SG, 2015-0908 ).

Publisher Copyright:
© 2016 The Authors

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

Keywords

  • Acute liver failure
  • CD39
  • CD73
  • HIF-1α

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