TY - JOUR
T1 - Proteomics and the analysis of proteomic data
T2 - an overview of current protein-profiling technologies.
AU - Gulcicek, Erol E.
AU - Colangelo, Christopher M.
AU - McMurray, Walter
AU - Stone, Kathryn
AU - Williams, Kenneth
AU - Wu, Terence
AU - Zhao, Hongyu
AU - Spratt, Heidi
AU - Kurosky, Alexander
AU - Wu, Baolin
PY - 2005/7
Y1 - 2005/7
N2 - In recent years, several proteomic methodologies have been developed that now make it possible to identify, characterize, and comparatively quantify the relative level of expression of hundreds of proteins that are coexpressed in a given cell type or tissue, or that are found in biological fluids such as serum. These advances have resulted from the integration of diverse scientific disciplines including molecular and cellular biology, protein/peptide chemistry, bioinformatics, analytical and bioanalytical chemistry, and the use of instrumental and software tools such as multidimensional electrophoretic and chromatographic separations and mass spectrometry. In this unit, some of the common protein-profiling technologies are reviewed, along with the accompanying data-analysis tools.
AB - In recent years, several proteomic methodologies have been developed that now make it possible to identify, characterize, and comparatively quantify the relative level of expression of hundreds of proteins that are coexpressed in a given cell type or tissue, or that are found in biological fluids such as serum. These advances have resulted from the integration of diverse scientific disciplines including molecular and cellular biology, protein/peptide chemistry, bioinformatics, analytical and bioanalytical chemistry, and the use of instrumental and software tools such as multidimensional electrophoretic and chromatographic separations and mass spectrometry. In this unit, some of the common protein-profiling technologies are reviewed, along with the accompanying data-analysis tools.
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M3 - Review article
C2 - 18428746
AN - SCOPUS:43749088043
SN - 1934-3396
VL - Chapter 13
SP - Unit 13.1
JO - Current protocols in bioinformatics / editoral board, Andreas D. Baxevanis ... [et al.]
JF - Current protocols in bioinformatics / editoral board, Andreas D. Baxevanis ... [et al.]
ER -