Abstract
A male infant of 16 months, of the Han race, died from subacute infantile mountain sickness in Lhasa (3600 m). At necropsy there was right ventricular hypertrophy secondary to muscularization of the pulmonary arteries and arterioles thought to have been induced by hypobaric hypoxia. In addition, there was intimal proliferation of myofibroblasts in the pulmonary arterioles, venules and veins. There were increased numbers within the bronchioles of pulmonary endocrine cells, containing calcitonin and bombesin, which could be related to hypoxia or trophic effects on the pulmonary vasculature. The relation of delayed effects of hypoxia to primary pulmonary hypertension is considered in this study.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 77-81 |
| Number of pages | 5 |
| Journal | Respiratory Medicine |
| Volume | 83 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1989 |
Bibliographical note
Funding Information:*Department of Pathology, University of Liverpool, Liverpool, t Department of Cardiac Medicine, Cardiothoracic Institute, London, London, U.K., ~Department of Pathology, People's Hospital of the Tibetan Autonomous Region of the People's Republic of China, Lhasa, §Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China and [IDepartment of Cardiology, Postgraduate Institute for Medical Education and Research, Chandigarh, India.
