Pulsatilloside A and anemoside A 3 protect PC12 cells from apoptosis induced by sodium cyanide and glucose deprivation

Xiang Dong Gao, Wen Cai Ye, Albert C.H. Yu, Yun Zhang, Ren Xiang Tan, Ming Li, W. L.Wendy Hsiao

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Using sodium cyanide (NaCN) and glucose deprivation induced cell injury in PC12 as an injury model, we investigated the protective effects of pulsatilloside A and anemoside A 3 on neurons. The results showed that PC12 cells under the NaCN-injury and glucose deprivation would undergo apoptosis. Additions of pulsatilloside A and anemoside A 3 , at dosages ranging from 0.1, 1 and 10μg/ml, protected PC12 cells from apoptosis determined by MTT, LDH release analysis, and flow cytometry measurement.

Original languageEnglish (US)
Pages (from-to)171-174
Number of pages4
JournalPlanta Medica
Volume69
Issue number2
DOIs
StatePublished - Feb 1 2003

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