Qs in the nucleus

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

The polyglutamine diseases include at least nine neurodegenerative disorders. Accumulation of mutant protein with a toxic gain-in function in the nucleus appears to be the pathological basis of these diseases. In this issue of Neuron, La Spada et al. (2001) provide insight into the cell specificity of pathology for a polyglutamine disease by relating SCA7-induced retinal degeneration to a disruption of the photoreceptor-specific transcription factor CRX.

Original languageEnglish (US)
Pages (from-to)875-876
Number of pages2
JournalNeuron
Volume31
Issue number6
DOIs
StatePublished - Sep 27 2001

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