Background Postmenopausal symptomatology has not been elucidated in large, long-term human clinical trials. Our objective was to measure quality of life in postmenopausal women aged 50–70 years. Methods A Menopause-Specific Quality of Life-Intervention (MENQOL) questionnaire was completed by women enrolled in the Minnesota Green Tea Trial (n = 932) to assess vasomotor, physical, sexual, and psychosocial symptoms in the years following menopause. Responses were coded; mean overall and domain scores ranged from 1 to 8. A higher score indicated more severe symptoms. Results Mean overall MENQOL scores were highest in women aged 50–54.9 years. A pattern of reduced symptom severity with increasing age was observed overall and within each domain. Women aged 50–54.9 years had more severe night sweats and sweating than other age groups (P ≤ 0.001) and more severe hot flashes than women aged ≥ 60 years (P ≪ 0.001). No differences between age groups were seen on mean score in the Sexual domain. Compared with women aged 50.0–54.9 years (the reference group), study participants aged 60–64.9 and ≥ 65 years had lower MENQOL scores in the Psychosocial domain (P = 0.029 and P ≪ 0.001). Women aged 50–54.9 years had more severe symptoms related to negative mood than women ≥65 years (P ≤ 0.009). Compared with women aged 50–54.9 years, those in the age groups 60–64.9 and ≥ 65 years had lower scores for “poor memory” (2.98 ± 1.75 and 2.66 ± 1.68 vs. 3.43 ± 1.87, P ≪ 0.001). Women ≥ 65 years reported lower scores for “feeling tired or worn out”, “difficulty sleeping”, and “lack of energy” than all other age groups (P ≤ 0.003). Conclusion The findings of this descriptive analysis of postmenopausal women may help clinicians counsel women about expectations and treatment options to address menopause-associated symptoms and the relationship between postmenopausal symptoms and overall health.
Bibliographical noteFunding Information:
Research reported in this publication was supported by the National Institutes of Health/National Cancer Institute grant R01 CA127236 and Award Number T32CA132670 from the National Cancer Institute . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute or the National Institutes of Health. The funding sources and study supplement provider did not contribute to the design or conduct of the study, nor to the writing or submission of this manuscript.
© 2017 Elsevier B.V.
- Breast cancer
- Green tea
- Postmenopausal women
- Quality of life